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一名30岁静脉吸毒者的苏云金芽孢杆菌菌血症:一例罕见病例报告

Bacillus thuringiensis Bacteremia in a 30-Year-Old Intravenous Drug User: A Report of a Rare Case.

作者信息

Barakat Salim, Kim Hyunwoo, Dankar Razan, Hewlett Chadik

机构信息

Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, USA.

Internal Medicine, Touro College of Osteopathic Medicine, New York, USA.

出版信息

Cureus. 2024 Oct 17;16(10):e71704. doi: 10.7759/cureus.71704. eCollection 2024 Oct.

DOI:10.7759/cureus.71704
PMID:39553074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11568792/
Abstract

is a gram-positive bacterium used in agriculture, with rare human infections that typically occur in immunocompromised individuals through environmental exposure. This report discusses the case of a 30-year-old intravenous drug user and polysubstance abuser who developed bacteremia due to . The patient originally presented with fever and leg ulcers from injection sites, and he was successfully treated with vancomycin. This case underscores the importance of recognizing atypical pathogens like in intravenous drug users, particularly when contaminated drug paraphernalia is involved. Although generally low in virulence, this bacterium can cause systemic infections under certain conditions. Prompt identification and treatment are crucial to prevent complications, highlighting the need for increased clinical awareness and appropriate microbiological investigations in this vulnerable population.

摘要

是一种用于农业的革兰氏阳性细菌,人类感染罕见,通常通过环境暴露在免疫功能低下的个体中发生。本报告讨论了一名30岁静脉吸毒者和多种药物滥用者因……而发生菌血症的病例。患者最初表现为发热和注射部位的腿部溃疡,他接受万古霉素治疗成功。该病例强调了识别静脉吸毒者中像……这样的非典型病原体的重要性,特别是当涉及受污染的吸毒用具时。虽然这种细菌的毒力一般较低,但在某些情况下可引起全身感染。及时识别和治疗对于预防并发症至关重要,突出了在这一脆弱人群中提高临床意识和进行适当微生物学调查的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eb4/11568792/df9ee1edcbe3/cureus-0016-00000071704-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eb4/11568792/f1f609d5e406/cureus-0016-00000071704-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eb4/11568792/df9ee1edcbe3/cureus-0016-00000071704-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eb4/11568792/f1f609d5e406/cureus-0016-00000071704-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5eb4/11568792/df9ee1edcbe3/cureus-0016-00000071704-i02.jpg

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本文引用的文献

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Whole genome sequencing of a novel Bacillus thuringiensis isolated from Assam soil.从阿萨姆邦土壤中分离出的新型苏云金芽孢杆菌的全基因组测序。
BMC Microbiol. 2023 Mar 31;23(1):91. doi: 10.1186/s12866-023-02821-0.
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Rapidly fatal infection with Bacillus cereus/thuringiensis: genome assembly of the responsible pathogen and consideration of possibly contributing toxins.迅速致命的蜡样芽胞杆菌/苏云金芽孢杆菌感染:致病病原体的基因组组装及可能存在的相关毒素的考虑。
Diagn Microbiol Infect Dis. 2021 Dec;101(4):115534. doi: 10.1016/j.diagmicrobio.2021.115534. Epub 2021 Sep 10.
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Infective Endocarditis in Persons Who Use Drugs: Epidemiology, Current Management, and Emerging Treatments.
药物滥用人群中的感染性心内膜炎:流行病学、当前管理和新兴治疗方法。
Infect Dis Clin North Am. 2020 Sep;34(3):479-493. doi: 10.1016/j.idc.2020.06.004.
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Bacillus thuringiensis: a successful insecticide with new environmental features and tidings.苏云金芽孢杆菌:一种具有新环境特征和前景的成功杀虫剂。
Appl Microbiol Biotechnol. 2017 Apr;101(7):2691-2711. doi: 10.1007/s00253-017-8175-y. Epub 2017 Feb 24.
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Bacillus thuringiensis Is an Environmental Pathogen and Host-Specificity Has Developed as an Adaptation to Human-Generated Ecological Niches.苏云金芽孢杆菌是一种环境病原体,宿主特异性的形成是对人类创造的生态位的一种适应。
Insects. 2013 Dec 24;5(1):62-91. doi: 10.3390/insects5010062.
6
Clinical characteristics and antimicrobial susceptibility of Bacillus cereus blood stream infections.蜡样芽孢杆菌血流感染的临床特征及抗菌药敏性
Ann Clin Microbiol Antimicrob. 2015 Sep 15;14:43. doi: 10.1186/s12941-015-0104-2.
7
A cluster of Bacillus cereus bacteremia cases among injection drug users.注射吸毒者中出现的一群蜡样芽孢杆菌菌血症病例。
Can J Infect Dis Med Microbiol. 2015 Mar-Apr;26(2):103-4. doi: 10.1155/2015/482309.
8
Acute infections in intravenous drug users.静脉注射吸毒者中的急性感染
Clin Med (Lond). 2013 Oct;13(5):511-3. doi: 10.7861/clinmedicine.13-5-511.
9
Nosocomial bacteremia caused by biofilm-forming Bacillus cereus and Bacillus thuringiensis.由形成生物膜的蜡样芽孢杆菌和苏云金芽孢杆菌引起的医院获得性菌血症。
Intern Med. 2009;48(10):791-6. doi: 10.2169/internalmedicine.48.1885. Epub 2009 May 15.
10
Wound botulism in injection drug users.注射吸毒者中的创伤性肉毒中毒
Emerg Infect Dis. 2007 Jun;13(6):942-3. doi: 10.3201/eid1306.061336.