Bagheri-Mohammadi Saeid, Karamivandishi Arezoo, Mahdavi Seif Ali, Siahposht-Khachaki Ali
Department of Paramedicine, Amol School of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Heliyon. 2024 Oct 23;10(21):e39744. doi: 10.1016/j.heliyon.2024.e39744. eCollection 2024 Nov 15.
Glioma or glioblastoma (GBM) is one of the aggressive and fatal primary cerebral malignancies, with the highest mortality rate among all brain-related tumors. Also, glioma mainly progresses as a more invasive phenotype after primary treatment. Cumulative evidence suggested that dysregulation of noncoding RNAs (ncRNAs) such as long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) are associated with tumor initiation, progression, and drug resistance, through epigenetic modifications, transcriptional, and post-transcriptional processes in the cells. Many scientific investigations have revealed that LncRNAs play important roles in various biological procedures linked with the development and progression of GBM. In recent years, it has been shown that dysregulation of molecular mechanisms in many LncRNAs such as MIR22HG, HULC, AGAP2-AS1, MALAT1, PVT1, TTTY14, HOTAIRM1, PTAR, LPP-AS2, LINC00336, and TINCR are connected with the GBM. Therefore, this scientific review paper focused on the molecular mechanisms of these LncRNAs in the context of GBM.
神经胶质瘤或胶质母细胞瘤（GBM）是侵袭性和致命性最强的原发性脑恶性肿瘤之一，在所有与脑相关的肿瘤中死亡率最高。此外，神经胶质瘤在初次治疗后主要表现为更具侵袭性的表型。越来越多的证据表明，长链非编码RNA（LncRNAs）和微小RNA（miRNAs）等非编码RNA（ncRNAs）的失调，通过细胞中的表观遗传修饰、转录和转录后过程，与肿瘤的发生、发展及耐药性相关。许多科学研究表明，LncRNAs在与GBM发生发展相关的各种生物学过程中发挥重要作用。近年来，研究表明，许多LncRNAs如MIR22HG、HULC、AGAP2-AS1、MALAT1、PVT1、TTTY14、HOTAIRM1、PTAR、LPP-AS2、LINC00336和TINCR的分子机制失调与GBM有关。因此，这篇科学综述文章聚焦于这些LncRNAs在GBM背景下的分子机制。
