Vijayan V K
Brain Res. 1986 Mar;390(2):259-70. doi: 10.1016/s0006-8993(86)80235-9.
Morphogenesis of the hippocampal mossy fiber synapses (MFSs) in fetal and postnatal rhesus monkeys was examined by electron microscopy. Typical invaginated MFSs were absent on gestation days 90 and 109 and were detected infrequently on day 132. In older fetuses and postnatal animals of 16 days and 9 months of age, the percentage of invaginated MFSs increased and the synapses exhibited increases in the number of invaginated spines and density of synaptic vesicles and greater maturity of the spines. At all ages, MFSs exhibited a wide range of maturity which may be correlated with the reported protracted generation of dentate granule cells in the rhesus monkey. The pattern of morphogenesis of MFSs in the monkey suggests that as in the rat, it is very likely that the mossy fibers contact pyramidal cells prior to the emergence of the 'thorny excrescences' and that this is followed by progressive maturation of the MFSs. The time-course of major morphogenetic modifications in MFSs in the rhesus monkey corresponds to the period of elaboration of complex spines and synapses in the dentate molecular layer. On this basis, it is suggested that these two processes are interrelated developmental events.
通过电子显微镜检查了胎儿期和出生后恒河猴海马苔藓纤维突触（MFSs）的形态发生。在妊娠第90天和第109天未发现典型的内陷型MFSs，在第132天偶尔能检测到。在年龄较大的胎儿以及出生后16天和9个月大的动物中，内陷型MFSs的百分比增加，突触的内陷棘数量、突触小泡密度增加，棘的成熟度更高。在所有年龄段，MFSs都表现出广泛的成熟度范围，这可能与恒河猴中报道的齿状颗粒细胞的长期生成有关。猴子中MFSs的形态发生模式表明，与大鼠一样，苔藓纤维很可能在“棘状赘生物”出现之前就与锥体细胞接触，随后MFSs逐渐成熟。恒河猴MFSs主要形态发生修饰的时间进程与齿状分子层中复杂棘和突触的形成期相对应。在此基础上，提示这两个过程是相互关联的发育事件。
