Chen Xiaoli, Gu Yixin, Wang Hairui, Zhou Guilan, Zhang Xin, Liu Chang, Shao Zhujun, Zhang Jianzhong, Zhang Maojun
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
China CDC Wkly. 2024 Nov 8;6(45):1177-1182. doi: 10.46234/ccdcw2024.237.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Lipooligosaccharides from () have a mimicry antigen structure with gangliosides, which explains the mechanism by which caused Guillain-Barré syndrome (GBS).
WHAT IS ADDED BY THIS REPORT?: All 12 strains with class R LOSs and specific serotypes were isolated from seagulls in south China. These emerging strains had ganglioside-mimicry antigen structures and possessed a high potential for triggering GBS.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Sialylated lipooligosaccharides (LOS) class R with GBS-associated serotypes isolated from seagulls highlight the risk of induced GBS around coastal or lakeside areas.
关于该主题已知的信息有哪些？：来自（）的脂寡糖具有与神经节苷脂相似的抗原结构，这解释了（）引发吉兰 - 巴雷综合征（GBS）的机制。
本报告新增了哪些内容？：所有12株具有R类脂寡糖和特定血清型的（）菌株均从中国南方的海鸥中分离得到。这些新出现的（）菌株具有神经节苷脂模拟抗原结构，并且具有引发GBS的高潜力。
对公共卫生实践有哪些启示？：从海鸥中分离出的具有与GBS相关血清型的唾液酸化脂寡糖（LOS）R类突出了沿海或湖边地区诱发GBS的风险。
