Ghiam Sean, Pirouz Ash, Adrean Sean D
Sackler School of Medicine, New York State/American Program of Tel Aviv University, Tel Aviv, Israel.
Retinal Consultants of Orange County, Fullerton, CA, USA.
J Vitreoretin Dis. 2024 Aug 22:24741264241271697. doi: 10.1177/24741264241271697.
To describe a potential new phenotypic presentation of pentosan polysulfate sodium maculopathy. An observational case was analyzed. A 55-year-old woman with interstitial cystitis who was treated with oral pentosan polysulfate sodium for 10 years presented with reports of decreased vision and metamorphopsia that had worsened over the past 3 months. On funduscopic examination, there were bilateral areas of retinal pigment epithelial hyperplasia inferior to the fovea with a surrounding halo of drusenoid material. Neurosensory retinal detachments with drusenoid deposition at the edges of the detachment were seen on spectral-domain optical coherence tomography. These findings could be mistaken for age-related macular degeneration, central serous retinopathy, Best disease, or adult vitelliform dystrophy. In this case, a review of pertinent medications assisted in making the diagnosis of toxic maculopathy. Proper diagnosis and prompt discontinuation of the inciting medication are necessary to avoid the risk for potentially irreversible retinal damage and vision loss.
描述戊聚糖多硫酸酯钠黄斑病变一种潜在的新表型表现。分析了1例观察性病例。一名55岁间质性膀胱炎女性，口服戊聚糖多硫酸酯钠治疗10年，出现视力下降和视物变形的症状，且在过去3个月内有所加重。眼底检查发现，双侧黄斑中心凹下方有视网膜色素上皮增生区域，周围有玻璃膜疣样物质晕环。光谱域光学相干断层扫描显示神经感觉层视网膜脱离，脱离边缘有玻璃膜疣样沉积。这些表现可能会被误诊为年龄相关性黄斑变性、中心性浆液性视网膜病变、Best病或成人卵黄样营养不良。在该病例中，对相关药物的审查有助于诊断中毒性黄斑病变。为避免潜在的不可逆视网膜损伤和视力丧失风险，正确诊断并及时停用致病药物是必要的。
