Zang Sha-Sha, Zhao Qing, Xiao Nuan, Liu Sha
Sha-Sha Zang, Department of Geratology and Special Hospital Ward, The Affiliated Hospital of Hebei University, Hebei, China.
Qing Zhao, Department of Geratology and Special Hospital Ward, The Affiliated Hospital of Hebei University, Hebei, China.
Pak J Med Sci. 2024 Nov;40(10):2379-2383. doi: 10.12669/pjms.40.10.8464.
To investigate the correlation between 25-hydroxyvitamin D and H-type hypertension in elderly patients, and to observe the clinical efficacy of vitamin D supplementation in those patients.
This was a retrospective study. One hundred and twenty elderly hypertensive patients treated at The Affiliated Hospital of Hebei University from June 2022 to June 2023 were randomly divided into Group-A (n=60) with hypertension and elevated homocysteine (Hcy) levels (H-type hypertension), and Group-B(n=60) with hypertension and normal Hcy levels. Blood levels of 25-hydroxyvitamin D and 24 hours ambulatory blood pressure were assessed in both groups of patients upon admission, with the correlation analysis performed simultaneously. The therapeutic effects were compared between the two groups.
Through Pearson correlation analysis, there were negative correlations of serum 25-hydroxyvitamin D levels with 24 hours SSD, 24 hours DSD, dnSBP, and nDBP(all p<0.05). After 12 weeks of treatment, the treatment group had higher 25-hydroxyvitamin D levels and lower 24 hours SBP, 24h DBP, dSBP, dDBP, nSBP, nDBP levels than those of the control group(p<0.05). After treatment, the treatment group had lower blood Hcy, IMT, TC, TG, and LDL-C levels(p<0.05), and higher HDL-C levels(p<0.05) than those of the control group.
Serum 25-hydroxyvitamin D levels in elderly patients with H-type hypertension have negative correlations with 24 hours SSD, 24 hours DSD, dnSBP, and nDBP. Oral vitamin D supplementation for H-type hypertensive patients exhibits significant therapeutic effects, with improvements in 24 hours ambulatory blood pressure monitoring results, blood lipid levels, IMT, and blood Hcy levels after treatment.
探讨老年患者25-羟基维生素D与H型高血压的相关性，并观察补充维生素D对这些患者的临床疗效。
这是一项回顾性研究。将2022年6月至2023年6月在河北大学附属医院接受治疗的120例老年高血压患者随机分为A组（n = 60），即高血压且同型半胱氨酸（Hcy）水平升高（H型高血压），和B组（n = 60），即高血压且Hcy水平正常。两组患者入院时均评估25-羟基维生素D血水平和24小时动态血压，并同时进行相关性分析。比较两组的治疗效果。
通过Pearson相关性分析，血清25-羟基维生素D水平与24小时收缩压标准差（SSD）、24小时舒张压标准差（DSD）、日间收缩压（dnSBP）和夜间舒张压（nDBP）均呈负相关（均p<0.05）。治疗12周后，治疗组的25-羟基维生素D水平高于对照组，24小时收缩压（SBP）、24小时舒张压（DBP）、日间收缩压（dSBP）、日间舒张压（dDBP）、夜间收缩压（nSBP）、夜间舒张压（nDBP）水平低于对照组（p<0.05）。治疗后，治疗组的血Hcy、内膜中层厚度（IMT）、总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平低于对照组（p<0.05），高密度脂蛋白胆固醇（HDL-C）水平高于对照组（p<0.05）。
老年H型高血压患者血清25-羟基维生素D水平与24小时SSD、24小时DSD、dnSBP和nDBP呈负相关。对H型高血压患者口服补充维生素D具有显著治疗效果，治疗后24小时动态血压监测结果、血脂水平、IMT和血Hcy水平均有改善。
