Yu Hai-Bo, Jia Ke-Feng, Wang Xing-Fen, Li Bao-Yu, Xin Qi
Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Department of Radiology, Tianjin Third Central Hospital, Tianjin 300170, China.
World J Gastrointest Oncol. 2024 Nov 15;16(11):4309-4314. doi: 10.4251/wjgo.v16.i11.4309.
In this editorial, we comment on an article by Xu . This article describes a case of crawling-type gastric adenocarcinoma (CRA) distinguished by its rare occurrence and diagnostic complexity. We reviewed the detailed case-report findings showcasing clinical, pathological, and molecular characteristics of CRA that shed light on its elusive nature and challenges for early detection and treatment. This case underscored the significance of advanced diagnostic tools such as endoscopic submucosal dissection. Emphasis was placed on the molecular peculiarities of CRA, including the higher mutation rates of genes such as and and the notable absence of amplification, differentiating it from more conventional forms of gastric adenocarcinoma. In this editorial, we advocate for a multidisciplinary approach to effectively manage this rare subtype and highlight the necessity for precision in both diagnostic and therapeutic strategies. Moreover, a heightened awareness urging the adoption of advanced diagnostic techniques and collaborative approaches is necessary among clinicians and researchers. We aim to contribute to the ongoing discourse in gastrointestinal oncology, emphasizing the importance of recognizing and addressing the complexities associated with rare cancer subtypes such as CRA.
在这篇社论中，我们对徐的一篇文章进行评论。本文描述了一例爬行型胃腺癌（CRA），其特点是罕见且诊断复杂。我们回顾了详细的病例报告结果，展示了CRA的临床、病理和分子特征，这些特征揭示了其难以捉摸的性质以及早期检测和治疗面临的挑战。该病例强调了诸如内镜下黏膜下剥离术等先进诊断工具的重要性。重点是CRA的分子特性，包括某些基因较高的突变率以及明显不存在特定基因扩增，这使其有别于更传统的胃腺癌形式。在这篇社论中，我们提倡采用多学科方法来有效管理这种罕见亚型，并强调诊断和治疗策略精准性的必要性。此外，临床医生和研究人员必须提高认识，敦促采用先进的诊断技术和协作方法。我们旨在为胃肠肿瘤学的持续讨论做出贡献，强调认识和应对与CRA等罕见癌症亚型相关的复杂性的重要性。
