Zhang Xianheng, Liu Jian
Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People's Republic of China.
Anhui University of Chinese Medicine, Hefei, Anhui Province, 230012, People's Republic of China.
Int J Gen Med. 2024 Nov 12;17:5203-5217. doi: 10.2147/IJGM.S499413. eCollection 2024.
Gout is a metabolic disease characterized by inflammatory arthritis caused by abnormal uric acid metabolism. It is often complicated with cardio-renal damage and vascular lesions. In recent years, the relationship between lipid metabolism and gout has attracted increasing attention. Changes in blood lipids in gout patients are often clinically detectable and closely related to uric acid metabolism and inflammatory response in gout. With the development of lipidomics, the changes in small lipid molecules and their metabolic pathways have been gradually discovered, yielding a greater understanding of the lipid metabolism changes in gout patients and their potential role in gout development. Through searching the literature on lipid metabolism in gout since 2000 in PubMed and Web of Science, this article reviewed lipid metabolism changes in gout patients and their role in the risk of gout, uric acid metabolism, inflammatory response, and comorbidities. Additionally, the strategies to regulate the abnormal lipid metabolism in gout have also been summarized from the aspects of drugs, diet, and exercise. These will provide a new perspective for understanding gout pathogenesis and its treatment and management.
痛风是一种代谢性疾病，其特征为尿酸代谢异常导致的炎症性关节炎。它常并发心肾损害和血管病变。近年来，脂质代谢与痛风之间的关系日益受到关注。痛风患者的血脂变化在临床上通常可检测到，且与痛风中的尿酸代谢和炎症反应密切相关。随着脂质组学的发展，已逐渐发现小脂质分子的变化及其代谢途径，从而对痛风患者的脂质代谢变化及其在痛风发展中的潜在作用有了更深入的了解。通过检索2000年以来PubMed和Web of Science上关于痛风脂质代谢的文献，本文综述了痛风患者的脂质代谢变化及其在痛风风险、尿酸代谢、炎症反应和合并症中的作用。此外，还从药物、饮食和运动等方面总结了调节痛风患者异常脂质代谢的策略。这些将为理解痛风发病机制及其治疗和管理提供新的视角。
