Simeonova-Brachot Iglika Ivancheva
Department of Obstetrics and Gynecology, University Hospital of Poitiers, Poitiers, France.
Ultrasound. 2024 Jun 20:1742271X241260220. doi: 10.1177/1742271X241260220.
The study aims to evaluate the role of the posterior hard palate angle in the prenatal diagnosis of cleft palate.
Stored images of the axial transverse view of the fetal secondary palate, obtained at three-level obstetric ultrasounds, were used to evaluate the posterior border of the hard palate. The study population comprised 63 consecutive pregnancies of unaffected cases and 17 pregnancies suspected for a cleft palate without cleft lip, including 7 cases of cleft palate, 4 cases of high-arched palate, and 6 false-positive cases.
The posterior angle of the hard palate was significantly larger in the cleft palate group than in the healthy controls and false-positive cases: 227° (±51°) vs 160° (±16°), < 0.0001; and 173° ± 18°, < 0.0001, respectively. Regression analysis revealed that reflex angle remained an independent risk factor for cleft palate (odds ratio, 58.67 (95% confidence interval 10-341)). The sensitivity and specificity of the posterior angle assessment were 73% and 96%, respectively.
The posterior hard palate angle could be an ultrasound marker of cleft palate without a cleft lip.
本研究旨在评估硬腭后角在腭裂产前诊断中的作用。
利用在三级产科超声检查时获取的胎儿继发腭轴位横断图像来评估硬腭后缘。研究人群包括63例连续的未受影响病例的妊娠以及17例疑似腭裂但无唇裂的妊娠，其中包括7例腭裂、4例高拱腭和6例假阳性病例。
腭裂组的硬腭后角显著大于健康对照组和假阳性病例：分别为227°（±51°）与160°（±16°），P<0.0001；以及173°±18°，P<0.0001。回归分析显示反射角仍是腭裂的独立危险因素（优势比，58.67（95%置信区间10 - 341））。后角评估的敏感性和特异性分别为73%和96%。
硬腭后角可能是无唇裂腭裂的超声标志物。
