Sethi Rajandeep Singh, Kaur Navjot, Patni Sanjeev, Sharma Prashant, Sharma Anjali, Hussaini Syed Shujatulla
Institute of Oncology, Indus Hospitals (Fatehgarh Sahib, Dera Bassi, Mohali), Fatehgarh Sahib, Punjab, India.
Department of Lab Medicine, Indus International Hospital (Indus Hospitals), Derabassi, Punjab, India.
Indian J Surg Oncol. 2024 Dec;15(4):891-900. doi: 10.1007/s13193-024-01976-0. Epub 2024 Jul 4.
Sentinel lymph node biopsy is currently the gold standard for clinically node-negative patients of carcinoma breast. Fluorescein is a safe, low-cost agent, and easily available. Fluorescein has shown a promising role in sentinel lymph node evaluation in carcinoma breast in combination with methylene blue dye with a detection rate of more than 90% and a false-negative rate of less than 10% in previous studies. This study aims to determine the detection rate and diagnostic accuracy of fluorescein and methylene blue dye in early breast cancer. The identification rate and false-negative rate of the combined blue and fluorescent dye method were 100% and 7.14% respectively. The accuracy of the combined blue and fluorescein dye method was 98.3%. The sensitivity, specificity, negative predictive value, and positive predictive value of the combined blue dye and fluorescein dye method were 92.8%, 100%, 97.8%, and 100% respectively. Thus, the combined blue and fluorescein dye method is an easy, safe, cost-effective, and reliable method of sentinel lymph node biopsy in early breast cancer patients.
前哨淋巴结活检目前是临床淋巴结阴性乳腺癌患者的金标准。荧光素是一种安全、低成本且易于获取的试剂。在先前的研究中，荧光素与亚甲蓝染料联合使用，在乳腺癌前哨淋巴结评估中显示出有前景的作用，检测率超过90%，假阴性率低于10%。本研究旨在确定荧光素和亚甲蓝染料在早期乳腺癌中的检测率和诊断准确性。联合使用蓝色染料和荧光染料方法的识别率和假阴性率分别为100%和7.14%。联合使用蓝色染料和荧光染料方法的准确性为98.3%。联合使用蓝色染料和荧光染料方法的敏感性、特异性、阴性预测值和阳性预测值分别为92.8%、100%、97.8%和100%。因此，联合使用蓝色染料和荧光染料方法是早期乳腺癌患者前哨淋巴结活检的一种简便、安全、经济有效且可靠的方法。
