Jin Xinyu, Cai Yijie, Ren Xiaolu
Department of Paediatrics, Shanxi Medical University, Taiyuan, China.
Department of Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Front Oncol. 2024 Nov 1;14:1410229. doi: 10.3389/fonc.2024.1410229. eCollection 2024.
This meta-analysis is conducted to evaluate the comparative diagnostic efficacy of Ga-PSMA PET vs. mpMRI in detecting local staging of prostate cancer(PCa).
A comprehensive search was conducted in the PubMed and Embase databases to identify publications up to February 2024. The analysis included studies that evaluated the direct comparison of Ga-PSMA PET and mpMRI for local staging of prostate cancer. The reliability of the analyzed studies was evaluated using the QUADAS-2 tool.
The meta-analysis included 10 articles involving 505 patients, which revealed that both Ga-PSMA PET and mpMRI had similar sensitivities and specificities in detecting extracapsular extension(ECE) and seminal vesicle invasion(SVI). The sensitivities for ECE were 0.56 (95% CI: 0.41-0.71) for Ga-PSMA PET and 0.57 (95% CI: 0.43-0.71) for mpMRI, and specificities were both 0.84 (Ga-PSMA PET 95% CI: 0.75-0.91, mpMRI 95% CI: 0.76-0.91).For SVI, sensitivities were 0.57 (95% CI: 0.46-0.68) for Ga-PSMA PET and 0.70 (95% CI: 0.60-0.80) for mpMRI, with specificities of 0.92 (95% CI: 0.86-0.96) for Ga-PSMA PET and 0.94 (95% CI: 0.89-0.98) for mpMRI. There were no notable variations in sensitivity or specificity between the two methods for detecting ECE and SVI ( = 0.89 and 0.93 for ECE, 0.09 and 0.57 for SVI).
This meta-analysis indicates that Ga-PSMA PET has similar sensitivity and specificity to mpMRI in local prostate cancer staging. Nevertheless, the limited study sample size calls for further, larger prospective studies to validate these findings.
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=522438, identifier CRD42024522438.
进行这项荟萃分析以评估镓-前列腺特异性膜抗原正电子发射断层扫描（Ga-PSMA PET）与多参数磁共振成像（mpMRI）在检测前列腺癌（PCa）局部分期方面的比较诊断效能。
在PubMed和Embase数据库中进行全面检索，以识别截至2024年2月的出版物。该分析纳入了评估Ga-PSMA PET与mpMRI对前列腺癌局部分期进行直接比较的研究。使用QUADAS-2工具评估所分析研究的可靠性。
该荟萃分析纳入了10篇文章，涉及505例患者，结果显示Ga-PSMA PET和mpMRI在检测包膜外侵犯（ECE）和精囊侵犯（SVI）方面具有相似的敏感性和特异性。对于ECE，Ga-PSMA PET的敏感性为0.56（95%置信区间：0.41 - 0.71），mpMRI的敏感性为0.57（95%置信区间：0.43 - 0.71），特异性均为0.84（Ga-PSMA PET 95%置信区间：0.75 - 0.91，mpMRI 95%置信区间：0.76 - 0.91）。对于SVI，Ga-PSMA PET的敏感性为0.57（95%置信区间：0.46 - 0.68），mpMRI的敏感性为0.70（95%置信区间：0.60 - 0.80），Ga-PSMA PET的特异性为0.92（95%置信区间：0.86 - 0.96），mpMRI的特异性为0.94（95%置信区间：0.89 - 0.98）。在检测ECE和SVI方面，两种方法在敏感性或特异性上没有显著差异（ECE的I² = 0.89和0.93，SVI的I² = 0.09和0.57）。
这项荟萃分析表明，Ga-PSMA PET在前列腺癌局部分期方面与mpMRI具有相似的敏感性和特异性。然而，研究样本量有限，需要进一步开展更大规模的前瞻性研究来验证这些发现。
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=522438，标识符CRD42O24522438。
