肿瘤负荷评分对肝细胞癌根治性切除术后患者预后的影响：一项单中心回顾性研究。

The impact of tumor burden score on prognosis in patients after radical resection of hepatocellular carcinoma: a single-center retrospective study.

作者信息

Huang Junzhang, Zhou Ying, Wei Suosu, Tang Yuntian, Zhang Qiuhuan, Tang Yi, Huang Wei, Mo Chongde, Dong Xiaofeng, Yang Jianrong

机构信息

Department of Hepatobiliary, Pancreas and Spleen Surgery, Guangxi Academy of Medical Sciences, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Department of Scientific Cooperation of Guangxi Academy of Medical Sciences, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

出版信息

Front Oncol. 2024 Nov 1;14:1359017. doi: 10.3389/fonc.2024.1359017. eCollection 2024.

DOI:10.3389/fonc.2024.1359017

PMID:39555448

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11563962/

Abstract

PURPOSE

This study examines the relationship between tumor burden score (TBS) and survival and recurrence following radical resection of hepatocellular carcinoma through a cohort study conducted in the Guangxi population of China.

METHODS

This cohort study eventually recruited 576 HCC patients undergoing radical resection of HCC in the People's Hospital of Guangxi Zhuang Autonomous Region during 2013-2022. After determining the best threshold TBS, all cases were grouped to evaluate the relationship between TBS versus overall survival (OS) and cumulative recurrence. Using X-Tile software, the best threshold TBS to judge patient prognostic outcome following radical resection of HCC was 10.77.

RESULTS

Kaplan-Meier curve analysis revealed that patients with high TBS showed considerably decreased OS relative to the control group, accompanied by an increased recurrence rate. According to multivariate Cox proportional regression, the patients with high TBS were associated with poorer OS (HR = 2.56, 95% CI 1.64-3.99, < 0.001) and recurrence-free survival (RFS) (HR = 1.55, 95% CI 1.02-2.35, < 0.001).

CONCLUSION

In patients undergoing radical resection for HCC, higher TBS was significantly related to shorter OS and RFS.

摘要

目的

本研究通过在中国广西人群中进行的队列研究，探讨肿瘤负荷评分（TBS）与肝细胞癌根治性切除术后生存及复发之间的关系。

方法

本队列研究最终纳入了2013年至2022年期间在广西壮族自治区人民医院接受肝细胞癌根治性切除的576例肝癌患者。确定最佳TBS阈值后，将所有病例分组以评估TBS与总生存期（OS）和累积复发之间的关系。使用X-Tile软件，判断肝癌根治性切除术后患者预后结局的最佳TBS阈值为10.77。

结果

Kaplan-Meier曲线分析显示，高TBS患者的OS相对于对照组显著降低，同时复发率增加。根据多因素Cox比例回归分析，高TBS患者的OS较差（HR = 2.56，95%CI 1.64 - 3.99，P < 0.001），无复发生存期（RFS）也较差（HR = 1.55，95%CI 1.02 - 2.35，P < 0.001）。