基于微流控技术的骨芯片构建与应用的研究进展。
Advances in the Construction and Application of Bone-on-a-Chip Based on Microfluidic Technologies.
机构信息
Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School and Hospital of Stomatology, Lanzhou University, Lanzhou, China.
School of Stomatology, Gansu Health Vocational College, Lanzhou, China.
出版信息
J Biomed Mater Res B Appl Biomater. 2024 Dec;112(12):e35502. doi: 10.1002/jbm.b.35502.
Bone-on-a-chip (BOC) models that based on microfluidic technology have widely applied to understand bone physiology and the pathogenesis of related diseases. In this review, we provide an overview of bone biology and related diseases, explain the advantages and applications of microfluidic technology in the construction of BOC models, and summarize their progress in physiology, pathology, and drug development. Finally, we discussed the problems to be solved and the future directions of microfluidic technology and BOC platforms, so as to provide a reference for researchers to design better BOC models.
骨芯片（BOC）模型基于微流控技术，已广泛应用于理解骨生理学和相关疾病的发病机制。在这篇综述中，我们提供了骨生物学和相关疾病的概述，解释了微流控技术在构建 BOC 模型中的优势和应用，并总结了它们在生理学、病理学和药物开发方面的进展。最后，我们讨论了微流控技术和 BOC 平台需要解决的问题和未来的方向，为研究人员设计更好的 BOC 模型提供参考。
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