Herlitz J, Helgesson I, Hjalmarson B M, Hjalmarson A, Jonsteg C, von Sudow B, Waldenström J
Cardiology. 1986;73(2):85-93. doi: 10.1159/000173988.
In 585 patients with a first myocardial infarction the enzymatically estimated infarct size was related to the clinical course during a 2-year follow-up. Infarct size was estimated from maximum heat-stable lactate dehydrogenase activity. A higher maximum serum activity was associated with a higher mortality rate, more treatment with diuretics, digitalis and antiarrhythmics and a lower frequency of return to work. Patients with smaller infarcts according to maximum serum activity, however, had a higher incidence of angina pectoris and a higher reinfarction rate. We conclude that although there is a strong association between serum enzyme activity and mortality during a 2-year follow-up, the relation with morbidity appears to be more complex.
在585例首次发生心肌梗死的患者中，通过酶法估算的梗死面积与2年随访期间的临床病程相关。梗死面积根据最大热稳定乳酸脱氢酶活性进行估算。最高血清活性越高，死亡率越高，使用利尿剂、洋地黄和抗心律失常药物的治疗越多，重返工作的频率越低。然而，根据最高血清活性判断梗死面积较小的患者，心绞痛发生率较高，再梗死率也较高。我们得出结论，虽然在2年随访期间血清酶活性与死亡率之间存在密切关联，但与发病率的关系似乎更为复杂。
