Dodd Rebecca J, Allen Judith E, Day Anthony J
Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Academic Health Science Centre, Manchester, United Kingdom.
Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Academic Health Science Centre, Manchester, United Kingdom.
mBio. 2024 Dec 11;15(12):e0260924. doi: 10.1128/mbio.02609-24. Epub 2024 Nov 18.
The polysaccharide hyaluronan (HA) is an important component of lung extracellular matrix that increases following infection with influenza or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hellman et al. (U. Hellman, E. Rosendal, J. Lehrstrand, J. Henriksson, et al., mBio 15:e01303-24, https://doi.org/10.1128/mbio.01303-24) show that fragmented HA accumulates in the lungs of coronavirus disease 2019 (COVID-19) patients, with systemic levels of HA being associated with reduced lung function 3-6 months after infection. This study provides novel insights into HA's role in COVID-19 pathology and its potential utility as a biomarker for disease severity. However, much remains to be understood about the lung HA matrix in COVID-19 and how it compares to other lung conditions. In particular, the role of HA-binding proteins in organizing HA into a crosslinked network is yet to be fully determined at a molecular level. This knowledge is crucial in understanding the inter-relationships between the structure of the HA matrix and the regulation of the immune response, and thus our ability to target HA therapeutically for improved outcomes in COVID-19.
多糖透明质酸（HA）是肺细胞外基质的重要组成部分，在感染流感或严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后会增加。赫尔曼等人（U. 赫尔曼、E. 罗森达尔、J. 莱斯特兰德、J. 亨里克松等人，《mBio》15:e01303 - 24，https://doi.org/10.1128/mbio.01303 - 24）表明，片段化的HA在2019冠状病毒病（COVID-19）患者的肺部积聚，HA的全身水平与感染后3至6个月肺功能下降有关。这项研究为HA在COVID-19病理中的作用及其作为疾病严重程度生物标志物的潜在用途提供了新的见解。然而，关于COVID-19中肺HA基质及其与其他肺部疾病的比较，仍有许多有待了解之处。特别是，HA结合蛋白在将HA组织成交联网络中的作用在分子水平上尚未完全确定。这些知识对于理解HA基质结构与免疫反应调节之间的相互关系至关重要，从而有助于我们在COVID-19中靶向HA进行治疗以改善治疗效果。
