Masoom Md, Khan Mohd Ashif
Department of Translational and Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard University, New Delhi, India.
Polim Med. 2024 Jul-Dec;54(2):105-111. doi: 10.17219/pim/189406.
Globally, skin cancer is the predominant form of cancer, with melanoma identified as its most deadly variant. Projections suggest a surge exceeding 50% in melanoma occurrences by 2040, underscoring the urgency for preventive interventions. Sulforaphane (SFN), a compound found in cruciferous vegetables, is recognized for its cancer-preventive capabilities, particularly against skin cancer. This study employed a rigorous systematic review of various databases, adhering to predefined inclusion criteria for study selection. Data extraction was conducted using a uniform template, and the quality of the included studies was evaluated through the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool, specifically designed for animal research. The review encompasses studies published in English from 2000 to 2023, culminating in the inclusion of 9 pertinent studies. The findings highlight SFN's capacity to act as a protective agent in preventing skin cancer in animal models. It demonstrated efficacy in curbing skin tumorigenesis triggered by assorted carcinogens, reducing the onset of skin tumors and impeding the growth and spread of skin cancer cells. Furthermore, SFN showed preventive effects against UVB-induced skin carcinogenesis by obstructing the activator protein 1 signaling pathway. Based on evidence from animal-based research, SFN emerges as a promising chemopreventive substance against skin cancer. Nevertheless, determining its optimal dosage, application duration and method of administration for human subjects remains pending. If its effectiveness is substantiated, SFN could complement or offer an alternative to existing preventive measures against skin cancer.
在全球范围内，皮肤癌是最主要的癌症形式，黑色素瘤是其最致命的变体。预测表明，到2040年黑色素瘤的发病率将激增超过50%，这凸显了预防干预措施的紧迫性。萝卜硫素（SFN）是十字花科蔬菜中发现的一种化合物，因其预防癌症的能力而受到认可，尤其是对皮肤癌的预防作用。本研究对各种数据库进行了严格的系统综述，遵循预定义的研究选择纳入标准。使用统一模板进行数据提取，并通过专门为动物研究设计的实验室动物实验系统评价中心（SYRCLE）偏倚风险工具评估纳入研究的质量。该综述涵盖了2000年至2023年以英文发表的研究，最终纳入了9项相关研究。研究结果突出了SFN在动物模型中预防皮肤癌时作为保护剂的能力。它在抑制各种致癌物引发的皮肤肿瘤发生方面显示出功效，减少皮肤肿瘤的发生，并阻碍皮肤癌细胞的生长和扩散。此外，SFN通过阻断激活蛋白1信号通路对紫外线B诱导的皮肤癌发生具有预防作用。基于动物研究的证据，SFN成为一种有前景的预防皮肤癌的化学预防物质。然而，确定其对人类受试者的最佳剂量、应用持续时间和给药方法仍有待确定。如果其有效性得到证实，SFN可以补充或替代现有的皮肤癌预防措施。
