Gouran Azin, Esmaeili Dooki Mohammadreza, Nikbakht Hossein-Ali, Mahmoodi Hassan, Pornasrolah Mohammad, Nikpour Maryam, Mehrabani Sanaz
Student Research Committee, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Non-communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Wien Med Wochenschr. 2024 Nov 18. doi: 10.1007/s10354-024-01062-8.
The prevalence of gastroesophageal reflux disease (GERD) in children is increasing in different societies. This study aims to investigate the value of mean platelet volume (MPV) for diagnosing esophagitis in children with GERD.
This cross-sectional study conducted at Amirkola Children's Hospital between 2022 and 2023 involved children aged 2 to 16 years diagnosed with GERD. The diagnosis was based on the GSQ-YC and GASP‑Q questionnaires. All patients underwent endoscopy, with a biopsy for pathology and a blood sample for MPV analysis. The data were then analyzed using SPSS software version 22 (IBM Corp., Armonk, NY, USA), with a significance level set at lower than 0.05.
The frequency of esophagitis among 194 participants was 39.7%. The overall sensitivity and specificity of MPV for diagnosing esophagitis in children were 64.63% and 52.14%, respectively (area under the curve [AUC] = 0.59). In terms of gender, the overall sensitivity and specificity of the MPV were 85.00% and 32.65% in boys and 70.27% and 51.47% in girls (AUC = 0.58 and AUC = 0.61, respectively). In terms of age, the overall sensitivity and specificity of MPV in children under 12 years were 52.46% and 62.26% and in children older than 12 years 87.5% and 36.36% (AUC = 0.58 and AUC = 0.55, respectively).
In summary, the results of this study indicate that MPV is not a reliable method for diagnosing esophagitis in children with GERD.
在不同社会中，儿童胃食管反流病（GERD）的患病率正在上升。本研究旨在探讨平均血小板体积（MPV）在诊断GERD患儿食管炎中的价值。
这项横断面研究于2022年至2023年在阿米科拉儿童医院进行，纳入了2至16岁诊断为GERD的儿童。诊断基于GSQ-YC和GASP-Q问卷。所有患者均接受了内窥镜检查，取活检进行病理检查，并采集血样进行MPV分析。然后使用SPSS 22版软件（美国纽约州阿蒙克市IBM公司）对数据进行分析，显著性水平设定为低于0.05。
194名参与者中食管炎的发生率为39.7%。MPV诊断儿童食管炎的总体敏感性和特异性分别为64.63%和52.14%（曲线下面积[AUC]=0.59）。在性别方面，MPV在男孩中的总体敏感性和特异性分别为85.00%和32.65%，在女孩中为70.27%和51.47%（AUC分别为0.58和0.61）。在年龄方面，12岁以下儿童MPV的总体敏感性和特异性分别为52.46%和62.26%，12岁以上儿童为87.5%和36.36%（AUC分别为0.58和0.55）。
总之，本研究结果表明，MPV不是诊断GERD患儿食管炎的可靠方法。
