Yu Xinwen, Liu Yufei, Wang Meiying, Jia Peng, Yang Shuo, Sun Fei, Jin Yuxin, Wang Xin, Guo Zixin, Zhao Guohong, Gao Bin
Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, Shaanxi, China.
Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China.
J Clin Endocrinol Metab. 2024 Nov 18. doi: 10.1210/clinem/dgae798.
Prevailing studies have shown the disruption effect of per- and polyfluoroalkyl substances (PFAS) on thyroid homeostasis. However, most studies focused on individual thyroid hormones.
To explore the associations between PFAS exposures and thyroid homeostasis parameters.
A total of 2386 adults from NHANES (2007-2008 and 2011-2012) were included. Thyroid homeostasis parameters included central and peripheral thyroid hormone sensitivity, calculated by thyroid hormones. Multivariable survey-weighted linear regressions were performed to determine the association between PFAS exposure and thyroid homeostasis parameters. The weighted quantile sum (WQS) and the quantile g-computation (QGC) models were used to estimate the mixed effects of co-exposures to PFAS.
The ratio of free triiodothyronine/free thyroxine (FT3/FT4) and the sum activity of peripheral deiodinases (SPINA-GD) were positively associated with perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid, perfluorononanoic acid and perfluorohexane sulfonic acid, respectively. However, no significant associations were observed between PFAS exposure and central thyroid sensitivity parameters. PFAS co-exposures was positively associated with FT3/FT4 (β = 0.013, P < 0.001) and SPINA-GD (β = 1.230, P < 0.001) in WQS models. Consistently, PFAS concentrations per quantile was linked to an increase in FT3/FT4 (β = 0.004, P = 0.002) and SPINA-GD (β = 0.392, P = 0.008) in GQC models, with PFOA having the highest weight in all models.
This study revealed that PFAS exposures may affect peripheral thyroid hormone sensitivity instead of central among U.S. general adults, enhancing our understanding of the correlation between PFAS exposure and thyroid hormones and providing insights into potential health implications.
现有研究表明，全氟和多氟烷基物质（PFAS）对甲状腺稳态具有破坏作用。然而，大多数研究集中在单一甲状腺激素上。
探讨PFAS暴露与甲状腺稳态参数之间的关联。
纳入了来自美国国家健康与营养检查调查（NHANES，2007 - 2008年和2011 - 2012年）的2386名成年人。甲状腺稳态参数包括通过甲状腺激素计算得出的中枢和外周甲状腺激素敏感性。进行多变量调查加权线性回归以确定PFAS暴露与甲状腺稳态参数之间的关联。采用加权分位数和（WQS）模型与分位数g计算（QGC）模型来估计PFAS共同暴露的混合效应。
游离三碘甲状腺原氨酸/游离甲状腺素比值（FT3/FT4）和外周脱碘酶总活性（SPINA - GD）分别与全氟辛酸（PFOA）、全氟辛烷磺酸、全氟壬酸和全氟己烷磺酸呈正相关。然而，未观察到PFAS暴露与中枢甲状腺敏感性参数之间存在显著关联。在WQS模型中，PFAS共同暴露与FT3/FT4（β = 0.013，P < 0.001）和SPINA - GD（β = 1.230，P < 0.001）呈正相关。同样，在GQC模型中，每一分位数的PFAS浓度与FT3/FT4（β = 0.004，P = 0.002）和SPINA - GD（β = 0.392，P = 0.008）的增加相关，在所有模型中PFOA的权重最高。
本研究表明，在美国普通成年人中，PFAS暴露可能影响外周甲状腺激素敏感性而非中枢甲状腺激素敏感性，增进了我们对PFAS暴露与甲状腺激素之间相关性的理解，并为潜在的健康影响提供了见解。
