Wang Beiying, Hong Wei, Wu Zhiping, Li Xiaocui
Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Environ Toxicol Pharmacol. 2024 Dec;112:104589. doi: 10.1016/j.etap.2024.104589. Epub 2024 Nov 16.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants linked to reproductive disruptions. This study investigated the relationship between PFAS exposure and missed miscarriage in a hospital-based, case-control study in Shanghai, China. There were 393 women in our research, including 198 cases and 195 controls. Concentrations of 30 PFAS in plasma were quantified using HPLC-MS/MS, and 15 PFAS were detected at a rate greater than 90 percent. PFOA, L-PFOS, and PFOS isomers were significantly higher in the cases than those in the controls. 13 PFAS showed significant positive associations with miscarriage risk after adjustment for confounders, particularly PFOA (OR: 2.99, 95 % CI: 1.96-4.68) and various PFOS isomers. BKMR analysis confirmed higher overall PFAS levels were associated with increased miscarriage risk. These findings highlight the potential reproductive toxicity of PFAS and underscore the need for further investigations and regulatory actions to mitigate PFAS exposure in pregnant women.
全氟和多氟烷基物质（PFAS）是与生殖紊乱有关的持久性环境污染物。本研究在中国上海进行了一项基于医院的病例对照研究，调查了PFAS暴露与稽留流产之间的关系。我们的研究中有393名女性，包括198例病例和195名对照。使用HPLC-MS/MS对血浆中30种PFAS的浓度进行定量，检测到15种PFAS的检出率超过90%。病例组中的全氟辛酸（PFOA）、直链全氟辛烷磺酸（L-PFOS）和全氟辛烷磺酸（PFOS）异构体显著高于对照组。在对混杂因素进行调整后，13种PFAS与流产风险呈显著正相关，尤其是PFOA（比值比：2.99，95%置信区间：1.96-4.68）和各种PFOS异构体。贝叶斯核机器回归（BKMR）分析证实，PFAS总体水平较高与流产风险增加有关。这些发现凸显了PFAS潜在的生殖毒性，并强调需要进一步调查和采取监管行动，以减少孕妇接触PFAS的情况。
