Dey Sandip, Ghosh Manik, Dev Abhimanyu
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Jharkhand, India.
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Jharkhand, India.
Gene. 2025 Feb 5;936:149099. doi: 10.1016/j.gene.2024.149099. Epub 2024 Nov 17.
Increasing morbidity and mortality in CRC is a potential threat to human health. The major challenges for better treatment outcomes are the heterogeneity of CRC cases, complicated molecular pathway cross-talks, the influence of gut dysbiosis in CRC, and the lack of multimodal target-specific drug delivery. The overexpression of many receptors in CRC cells may pave the path for targeting them with multiple ligands. The design of a more target-specific drug-delivery device with multiple ligand-functionalized, green-synthesized silver nanoparticles is highly promising and may also deliver other approved chemotherapeutic agents. This review presents the various aspects of colorectal cancer and over-expressed receptors that can be targeted with appropriate ligands to enhance the specific drug delivery potency of green synthesised silver nanoparticles. This review aims to broaden further research into this multi-ligand functionalised, safer and effective silver nano drug delivery system.
结直肠癌发病率和死亡率的不断上升对人类健康构成了潜在威胁。改善治疗效果面临的主要挑战包括结直肠癌病例的异质性、复杂的分子途径相互作用、肠道微生物群失调对结直肠癌的影响以及缺乏多模式靶向特异性药物递送。结直肠癌细胞中许多受体的过度表达可能为用多种配体靶向这些受体铺平道路。设计一种具有多种配体功能化、绿色合成的银纳米颗粒的更具靶向特异性的药物递送装置极具前景，并且还可以递送其他已获批的化疗药物。本综述介绍了结直肠癌的各个方面以及可以用适当配体靶向的过度表达受体，以增强绿色合成银纳米颗粒的特异性药物递送效力。本综述旨在进一步拓展对这种多配体功能化、更安全有效的银纳米药物递送系统的研究。
