Li Hua, Cao Xiao, Wu Hao, Dong Dandan
Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China.
Department of Rehabilitation, Rehabilitation Hospital Affiliated to National Research Center for Rehabilitation Technical Aids, Beijing, 100176, China.
Mol Biotechnol. 2024 Nov 19. doi: 10.1007/s12033-024-01308-1.
To explore the relationship between BigET-1 and cardiac remodeling in hypertrophic obstructive cardiomyopathy (HOCM). A retrospective analysis was conducted on the data of 150 HOCM patients in a hospital from September 2021 to August 2023. According to the 2015 American Ultrasound Society's recommended standards for quantifying adult UGG cardiac lumen, left atrial enlargement is defined as having a left atrial diameter greater than 40 mm in males and greater than 38 mm in females. 150 HOCM patients were divided into a left atrial normal group (n = 97) and a left atrial enlargement group (n = 53). Comprehensive patient data were collected, including BigET-1in plasma, N-Terminalpro-B-TypeNatriureticPeptide (NT-pro-BNP), and High-sensitive C-reactive protein (Hs-CRP), as well as cardiac magnetic resonance imaging (CMR) imaging data. The relationship between BigET-1 levels and cardiac remodeling was analyzed. The two groups had no statistical difference in gender, age, heart rate, dyspnea, angina pectoris, etc. (P > 0.05). The χ-test showed that patients in the left atrial enlargement group had an increased proportion of atrial fibrillation compared to those in the left atrial normal group (P < 0.05). Non parametric tests showed that the Big ET-1 and NT-pro-BNP in the left atrial enlargement group were significantly higher than those in the left atrial normal group (P < 0.05). The t-test results showed that there were statistical differences in Hs-CRP, left atrial anteroposterior diameter, interventricular septum thickness, and LVEDV between the left atrial enlargement group and the left atrial normal group (P < 0.05). Pearson correlation analysis showed that Big ET-1 was positively correlated withNT-pro-BNP, Hs-CRP, left atrial anteroposterior diameter, and interventricular septum thickness (P < 0.05). The multiple linear regression analysis showed that Big ET-1 was positively correlated with NT-pro-BNP and LADap (P < 0.05). In HOCM patients with atrial enlargement, the Big ET-1 is significantly elevated. Cardiac remodeling is more pronounced, indicating that Big ET-1 plays a role in cardiac remodeling in HOCM patients.
探讨大内皮素-1（BigET-1）与肥厚型梗阻性心肌病（HOCM）心脏重塑之间的关系。对某医院2021年9月至2023年8月期间150例HOCM患者的数据进行回顾性分析。根据2015年美国超声学会推荐的成人超声心动图心脏腔量化标准，左心房扩大定义为男性左心房直径大于40mm，女性大于38mm。将150例HOCM患者分为左心房正常组（n = 97）和左心房扩大组（n = 53）。收集患者的综合数据，包括血浆中的BigET-1、N末端B型利钠肽原（NT-pro-BNP）、高敏C反应蛋白（Hs-CRP）以及心脏磁共振成像（CMR）图像数据。分析BigET-1水平与心脏重塑之间的关系。两组在性别、年龄、心率、呼吸困难、心绞痛等方面无统计学差异（P > 0.05）。χ检验显示，与左心房正常组相比，左心房扩大组患者房颤比例增加（P < 0.05）。非参数检验显示，左心房扩大组的Big ET-1和NT-pro-BNP显著高于左心房正常组（P < 0.05）。t检验结果显示，左心房扩大组与左心房正常组在Hs-CRP、左心房前后径、室间隔厚度和左心室舒张末期容积方面存在统计学差异（P < 0.05）。Pearson相关性分析显示，Big ET-1与NT-pro-BNP、Hs-CRP、左心房前后径和室间隔厚度呈正相关（P < 0.05）。多元线性回归分析显示，Big ET-1与NT-pro-BNP和左心房前后径呈正相关（P < 0.05）。在伴有心房扩大的HOCM患者中，Big ET-1显著升高。心脏重塑更为明显，表明Big ET-1在HOCM患者的心脏重塑中起作用。
