Riva Anna, Brasola Eleonora, Sforza Sofia Elena, Marfone Mirella, Biso Francesco, Nacinovich Renata
Department of Child Neuropsychiatry, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Department of Enterprise Engineering, Tor Vergata University of Rome, Rome, Italy.
Eur Eat Disord Rev. 2025 Mar;33(2):434-443. doi: 10.1002/erv.3155. Epub 2024 Nov 18.
Anorexia nervosa and borderline personality disorder are often associated and share some core elements, including emotional dysregulation and affective instability. Nevertheless, the association of these two conditions in adolescence is still little studied.
The present study aims at investigating, through a multidimensional assessment, the psychopathological characteristics of adolescents affected by anorexia nervosa in comorbidity with borderline personality disorder on a sample of 127 female adolescents, through the comparison with adolescents with borderline personality disorders and adolescents with anorexia nervosa. All participants completed a validated psychometric battery assessing alexithymia (Toronto Alexithymia Scale-20), depression (Children's Depression Inventory), psychological symptoms (Symptom Checklist-90-Revised) and psychological symptoms relevant in eating disorders (Eating Disorders Inventory-3).
Adolescents with anorexia nervosa in comorbidity with borderline personality disorder show intermediate features between the two disorders individually in the general psychopathological profile, but a peculiar psychological profile regarding the eating symptomatology, with worse features compared to adolescents with the sole anorexia nervosa.
Results suggest a peculiar clinical and psychopatological endophenotype in adolescents with anorexia nervosa in comorbidity with borderline personality disorders, indicating the need to define specific and tailored treatment for this population.
神经性厌食症与边缘型人格障碍常相关联且有一些共同的核心要素，包括情绪调节障碍和情感不稳定。然而，这两种情况在青少年中的关联仍鲜少被研究。
本研究旨在通过多维度评估，对127名女性青少年样本中合并边缘型人格障碍的神经性厌食症青少年的心理病理特征进行调查，与边缘型人格障碍青少年和神经性厌食症青少年进行比较。所有参与者都完成了一套经过验证的心理测量量表，评估述情障碍（多伦多述情障碍量表-20）、抑郁（儿童抑郁量表）、心理症状（症状自评量表-90修订版）以及饮食失调相关的心理症状（饮食失调量表-3）。
合并边缘型人格障碍的神经性厌食症青少年在一般心理病理特征方面表现出介于这两种障碍各自特征之间的中间特征，但在饮食症状方面有独特的心理特征，与单纯神经性厌食症青少年相比特征更差。
结果表明合并边缘型人格障碍的神经性厌食症青少年存在独特的临床和心理病理内表型，这表明需要为该人群确定具体且量身定制的治疗方法。
