Chaiyakulsil Chanapai
Division of Pediatric Critical Care, Department of Pediatrics, Thammasat University Hospital, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Acute Crit Care. 2024 Nov;39(4):600-610. doi: 10.4266/acc.2024.01011. Epub 2024 Nov 18.
Long-term survival data for critically ill children discharged to post-intensive care clinics are scarce, especially in Asia. The main objective of this study was to assess the prevalence of post-intensive-care morbidity among pediatric intensive care unit (PICU) survivors at 1 month and 1 year after hospital discharge and to identify the associated risk factors.
We conducted a retrospective chart review of all children aged 1 month to 15 years who were admitted to the PICU for >48 hours from July 2019 to July 2022 and visited a post-intensive-care clinic 1 month and 1 year after hospital discharge. Post-intensive care morbidity was defined using the Pediatric Cerebral Performance Category (PCPC). Descriptive statistics, univariate, and multivariate analyses were conducted.
A total of 111 children visited the clinic at 1 month, and 100 of these children visited the clinic at 1 year. Only 39 of 111 children (35.2%) had normal PCPC assessments at 1 month, while 54 of 100 (54.0%) were normal at 1 year. Baseline developmental delays were significantly associated with any degree of disability and at least moderate disability at both time points. Mechanical ventilation for >7 days was associated with at least moderate disability at both time points, while PICU stay >7 days was significantly associated with moderate disability at 1 month and any degree of disability at 1 year.
A substantial percentage of PICU survivors had persistent disabilities even 1 year after critical illness. A structured multidisciplinary post-intensive-care follow-up plan is warranted to provide optimal care for such children.
关于重症患儿出院后到重症监护后门诊随访的长期生存数据稀缺,尤其是在亚洲。本研究的主要目的是评估儿科重症监护病房(PICU)幸存者出院后1个月和1年时重症监护后发病的患病率,并确定相关危险因素。
我们对2019年7月至2022年7月期间入住PICU超过48小时、年龄在1个月至15岁之间且出院后1个月和1年到重症监护后门诊就诊的所有儿童进行了回顾性病历审查。使用儿科脑功能表现分类(PCPC)定义重症监护后发病情况。进行了描述性统计、单因素和多因素分析。
共有111名儿童在1个月时到门诊就诊,其中100名儿童在1年时到门诊就诊。111名儿童中只有39名(35.2%)在1个月时PCPC评估正常,而100名中的54名(54.0%)在1年时正常。基线发育迟缓在两个时间点均与任何程度的残疾和至少中度残疾显著相关。机械通气超过7天在两个时间点均与至少中度残疾相关,而PICU住院时间超过7天在1个月时与中度残疾显著相关,在1年时与任何程度的残疾显著相关。
即使在危重症发生1年后,仍有相当比例的PICU幸存者存在持续性残疾。有必要制定结构化的多学科重症监护后随访计划,为这些儿童提供最佳护理。