三阴性乳腺癌发病机制研究进展。
Advances in the Understanding of the Pathogenesis of Triple-Negative Breast Cancer.
机构信息
School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
College of Life Sciences and Technology, Shandong Second Medical University, Weifang, China.
出版信息
Cancer Med. 2024 Nov;13(22):e70410. doi: 10.1002/cam4.70410.
BACKGROUND
Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by high aggressiveness, high malignancy, and poor prognosis compared to other breast cancer subtypes.
OBJECTIVE
This review aims to explore recent advances in understanding TNBC and to provide new insights and potential references for clinical treatment.
METHODS
We examined current literature on TNBC to analyze molecular subtypes, genetic mutations, signaling pathways, mechanisms of drug resistance, and emerging therapies.
RESULTS
Findings highlight key aspects of TNBC's molecular subtypes, relevant mutations, and pathways, alongside emerging treatments that target drug resistance mechanisms.
CONCLUSION
These insights into TNBC pathogenesis may help guide future therapeutic strategies and improve clinical outcomes for patients with TNBC.
背景
与其他乳腺癌亚型相比，三阴性乳腺癌（TNBC）是一种具有高度侵袭性、高恶性和预后不良等特点的异质性疾病。
目的
本综述旨在探讨 TNBC 的最新研究进展，并为临床治疗提供新的见解和潜在参考。
方法
我们查阅了关于 TNBC 的现有文献，以分析分子亚型、遗传突变、信号通路、耐药机制和新兴疗法。
结果
研究结果强调了 TNBC 分子亚型、相关突变和通路的关键方面，以及针对耐药机制的新兴治疗方法。
结论
这些对 TNBC 发病机制的深入了解可能有助于指导未来的治疗策略，并改善 TNBC 患者的临床结局。
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