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Editorial: The role of retinoic acid signaling in maintenance and regeneration of the CNS: from mechanisms to therapeutic targeting.社论：视黄酸信号在中枢神经系统维持与再生中的作用：从机制到治疗靶点
Front Mol Neurosci. 2024 Nov 4;17:1491745. doi: 10.3389/fnmol.2024.1491745. eCollection 2024.
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Expression of nuclear retinoic acid receptor and retinoid X receptor mRNA in the cornea and conjunctiva.核视黄酸受体和视黄醇X受体mRNA在角膜和结膜中的表达。
Curr Eye Res. 1998 May;17(5):462-9. doi: 10.1076/ceyr.17.5.462.5189.
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Endogenous retinoic acid receptor (RAR)-retinoid X receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes. Binding of ligands to RAR only is sufficient for RAR-RXR heterodimers to confer ligand-dependent activation of hRAR beta 2/RARE (DR5).内源性视黄酸受体（RAR）-视黄醛X受体（RXR）异源二聚体是调节成年人类角质形成细胞中类视黄醇反应元件的主要功能形式。仅配体与RAR结合就足以使RAR-RXR异源二聚体赋予hRARβ2/RARE（DR5）依赖配体的激活作用。
J Biol Chem. 1995 Feb 17;270(7):3001-11. doi: 10.1074/jbc.270.7.3001.
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Retinoic acid differentially regulates retinoic acid receptor-mediated pathways in the Hep3B cell line.维甲酸对Hep3B细胞系中维甲酸受体介导的信号通路具有差异性调节作用。
Exp Cell Res. 1998 Jan 10;238(1):241-7. doi: 10.1006/excr.1997.3851.
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Retinoid X receptor-specific retinoids inhibit the ability of retinoic acid receptor-specific retinoids to increase the level of insulin-like growth factor binding protein-3 in human ectocervical epithelial cells.维甲酸X受体特异性类视黄醇抑制维甲酸受体特异性类视黄醇提高人宫颈外膜上皮细胞中胰岛素样生长因子结合蛋白-3水平的能力。
Cancer Res. 1996 Apr 15;56(8):1794-9.
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Retinoid receptors cause distortion of the retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter.维甲酸受体导致磷酸烯醇式丙酮酸羧激酶基因启动子中的维甲酸反应元件发生畸变。
Biochem J. 1995 Sep 1;310 ( Pt 2)(Pt 2):483-90. doi: 10.1042/bj3100483.
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Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid.视黄酸受体和类视黄醇X受体在全反式视黄酸抑制细胞凋亡中的选择性作用。
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Comparison of phenotypic and global gene expression changes in Xenopus tropicalis embryos induced by agonists of RAR and RXR.热带爪蟾胚胎中视黄酸受体（RAR）和视黄醇X受体（RXR）激动剂诱导的表型和全基因表达变化的比较
Toxicol Appl Pharmacol. 2017 Sep 1;330:40-47. doi: 10.1016/j.taap.2017.07.004. Epub 2017 Jul 6.
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Retinoic acid receptor and retinoid X receptor expression in retinoic acid-resistant human tumor cell lines.视黄酸受体和类视黄醇X受体在视黄酸耐药性人肿瘤细胞系中的表达
Mol Carcinog. 1993;8(2):112-22. doi: 10.1002/mc.2940080208.
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Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes.类视黄醇对大鼠肝脏微粒体代谢及细胞色素P450的影响。维甲酸受体/类视黄醇X受体选择性与对代谢酶影响之间的相关性。
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本文引用的文献

1
The Promise of Retinoids in the Treatment of Cancer: Neither Burnt Out Nor Fading Away.维甲酸在癌症治疗中的前景：并非日薄西山，亦非渐趋式微。
Cancers (Basel). 2023 Jul 8;15(14):3535. doi: 10.3390/cancers15143535.
2
Novel therapeutic approaches to target neurodegeneration.靶向神经退行性变的新型治疗方法。
Br J Pharmacol. 2023 Jul;180(13):1651-1673. doi: 10.1111/bph.16078. Epub 2023 Apr 26.
3
Tretinoin Review With Newer Formulations: Providing Effective and Tolerable Solutions in Clinical Practice.
J Drugs Dermatol. 2023 Jan 1;22(1):35-40. doi: 10.36849/JDD.7146.
4
Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model.维甲酸通过调节小白蛋白预防缺血性中风模型中的神经元损伤。
Neurochem Res. 2023 Feb;48(2):487-501. doi: 10.1007/s11064-022-03769-9. Epub 2022 Oct 16.
5
Therapeutic insights elaborating the potential of retinoids in Alzheimer's disease.阐述维甲酸在阿尔茨海默病中潜在作用的治疗见解。
Front Pharmacol. 2022 Aug 23;13:976799. doi: 10.3389/fphar.2022.976799. eCollection 2022.
6
Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement.维 A 酸 X 受体：核受体的细胞和生化作用及其在神经病理学中的作用。
Mol Neurobiol. 2022 Apr;59(4):2027-2050. doi: 10.1007/s12035-021-02709-y. Epub 2022 Jan 11.
7
Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson's Disease.维生素 A 代谢在帕金森病发病机制中的作用和机制。
J Parkinsons Dis. 2021;11(3):949-970. doi: 10.3233/JPD-212671.
8
Retinoic acid increases phagocytosis of myelin by macrophages.维甲酸可增强巨噬细胞吞噬髓磷脂。
J Cell Physiol. 2021 May;236(5):3929-3945. doi: 10.1002/jcp.30137. Epub 2020 Nov 9.
9
Recent advances in the design of RAR α and RAR β agonists as orally bioavailable drugs. A review.新型 RARα 和 RARβ 激动剂的设计：口服生物利用度药物的进展。一篇综述。
Bioorg Med Chem. 2020 Oct 15;28(20):115664. doi: 10.1016/j.bmc.2020.115664. Epub 2020 Jul 29.
10
Administration of all-trans retinoic acid after experimental traumatic brain injury is brain protective.实验性创伤性脑损伤后给予全反式维甲酸具有脑保护作用。
Br J Pharmacol. 2020 Nov;177(22):5208-5223. doi: 10.1111/bph.15259. Epub 2020 Oct 23.

Editorial: The role of retinoic acid signaling in maintenance and regeneration of the CNS: from mechanisms to therapeutic targeting.

作者信息

Corcoran Jonathan P T, Mey Jörg

机构信息

Neuroscience Drug Discovery Unit, Wolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London, United Kingdom.

Hospital Nacional de Parapléjicos, Toledo, Spain.

出版信息

Front Mol Neurosci. 2024 Nov 4;17:1491745. doi: 10.3389/fnmol.2024.1491745. eCollection 2024.

DOI:10.3389/fnmol.2024.1491745
PMID:39558937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11570587/
Abstract
摘要