Zand Vahid, Baradaranfar Mohammadhossein, Movahedinaini Said, Mandegari Mohammad, Meybodian Mojtaba, Vaziribozorg Sedighe, Ahmadizadeh Jahanbaz
Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Transplantation Research Center and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5500-5504. doi: 10.1007/s12070-024-05018-7. Epub 2024 Aug 30.
The aim of this study was to investigate the effect of total thyroidectomy on serum levels of trace elements, namely zinc and copper, in patients with thyroid diseases. In this cross-sectional study, 42 patients with thyroid diseases according to laboratory and fine needle aspiration (FNA) results divided into two groups, including differentiated thyroid cancer group (papillary and follicular) and non-cancerous group (MNG: Multinodular goiter). Before the surgery, blood sample was taken to investigate the zinc and copper levels. The patients underwent total thyroidectomy. Four days after the surgery, serum zinc and copper levels were investigated again and compared. There was no significant difference in frequency of zinc ( value = 0.99) and copper ( value = 0.70) level in patients undergoing total thyroidectomy before and after the surgery. Without considering the diagnosis (MNG and PTC), zinc levels decreased significantly after the surgery ( value = 0.01) but copper levels did not differ significantly ( value = 0.93) before and after the surgery. In patients diagnosed with PTC, a significant decrease in zinc level was observed ( value = 0.04) after the surgery but the difference between the copper before and after the intervention was not significant ( value = 0.35). In patients diagnosed with MNG, no significant decrease in zinc level ( value = 0.14) and copper level ( value = 0.80) was observed after the surgery. According to the results of this study zinc serum levels had a significant decrease in patients who underwent total thyroidectomy 4 days after the surgery.
本研究旨在探讨甲状腺全切除术对甲状腺疾病患者血清微量元素（即锌和铜）水平的影响。在这项横断面研究中，根据实验室检查和细针穿刺（FNA）结果，将42例甲状腺疾病患者分为两组，包括分化型甲状腺癌组（乳头状和滤泡状）和非癌组（MNG：多结节性甲状腺肿）。手术前，采集血样以检测锌和铜水平。患者接受甲状腺全切除术。手术后4天，再次检测血清锌和铜水平并进行比较。甲状腺全切除患者手术前后锌（值 = 0.99）和铜（值 = 0.70）水平的频率无显著差异。不考虑诊断情况（MNG和PTC），手术后锌水平显著下降（值 = 0.01），但手术前后铜水平无显著差异（值 = 0.93）。在诊断为PTC的患者中，手术后观察到锌水平显著下降（值 = 0.04），但干预前后铜水平的差异不显著（值 = 0.35）。在诊断为MNG的患者中，手术后锌水平（值 = 0.14）和铜水平（值 = 0.80）均无显著下降。根据本研究结果，甲状腺全切除术后4天患者的血清锌水平显著下降。
