Mathews-Roth M M
Dermatol Clin. 1986 Apr;4(2):335-9.
At present, three classes of compounds are used as systemic photoprotective agents, but only for specific indications, not for general use in healthy individuals. Beta-carotene prevents or lessens photosensitivity in most patients with erythropoietic protoporphyria and in some patients with other photosensitivity diseases. The antimalarial drugs can clear up skin lesions in patients with polymorphous light eruption and solar urticaria who cannot obtain relief with topical sunscreens and in some patients with porphyria cutanea tarda. Oral psoralens and controlled exposure to sunlight or artificial sources of UVA radiation can increase tolerance to sunlight in fair-skinned individuals and in certain patients with vitiligo or polymorphous light eruption.
目前，三类化合物被用作系统性光保护剂，但仅用于特定适应症，并非用于健康个体的常规用途。β-胡萝卜素可预防或减轻大多数红细胞生成性原卟啉症患者以及一些其他光敏性疾病患者的光敏反应。抗疟药可清除多形性日光疹和日光性荨麻疹患者的皮肤损害，这些患者使用外用防晒霜无法缓解，也可用于一些迟发性皮肤卟啉症患者。口服补骨脂素并控制暴露于阳光或人工紫外线辐射源下，可提高白皮肤个体以及某些白癜风或多形性日光疹患者对阳光的耐受性。
