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作者信息
Eltelety Ahmad Mohamed, Zaki Amir, Dewidar Hazem, Anis Shady Elia, Batawi Ahmed El, Nassar Ahmed Amin
机构信息
Otolaryngology Department, Al Kasr Al Ainy School of Medicine, Cairo University, Giza, 11562 Egypt.
Pathology Department, Al Kasr Al Ainy School of Medicine, Cairo University, Giza, 11562 Egypt.
出版信息
Indian J Otolaryngol Head Neck Surg. 2024 Dec;76(6):5513-5520. doi: 10.1007/s12070-024-05021-y. Epub 2024 Sep 19.
The purpose of this study was to evaluate the incidence and predictors of malignant soft tissue deposits (MSTDs) in advanced laryngeal carcinoma. MSTDs prognostic value on locoregional recurrence within 2 years after curative surgery was also studied. 40 patients with cT3/cT4 N0 laryngeal squamous cell carcinoma (SCC) were prospectively involved in the study. Soft tissue specimens were histopathologically examined for MSTDs. MSTDs were observed in 4 patients. Six patients had extranodal extension (ENE), four of whom showed MSTDs. All patients with MSTDs had associated comorbidities. cTNM staging, preoperative tracheostomy, tumor grade and surgical margins were not related to the incidence of MSTDs. The incidence of MSTDs in our report was less than that previously reported in the literature. MSTDs did not influence locoregional recurrence and did not influence the overall outcome. MSTDs were less significant as a prognostic factor in comparison to other factors such as ENE.
本研究的目的是评估晚期喉癌中恶性软组织沉积（MSTDs）的发生率及预测因素。同时还研究了MSTDs对根治性手术后2年内局部区域复发的预后价值。40例cT3/cT4 N0喉鳞状细胞癌（SCC）患者前瞻性地纳入本研究。对软组织标本进行组织病理学检查以确定是否存在MSTDs。4例患者观察到MSTDs。6例患者有淋巴结外扩展（ENE），其中4例显示有MSTDs。所有有MSTDs的患者均伴有合并症。cTNM分期、术前气管切开术、肿瘤分级及手术切缘与MSTDs的发生率无关。我们报告中MSTDs的发生率低于先前文献报道。MSTDs不影响局部区域复发，也不影响总体结局。与ENE等其他因素相比，MSTDs作为预后因素的意义较小。
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