Department of Pharmacy, College of Health Sciences, Debre Tabor University, PO Box 272, Debre Tabor, Ethiopia.
Department of Pharmacy, College of Health Sciences, Debre Markos University, PO Box 269, Debre Markos, Ethiopia.
Biomed Res Int. 2024 Nov 11;2024:5577862. doi: 10.1155/2024/5577862. eCollection 2024.
About 80% of pregnant women use at least one medication during their pregnancy period. Many drugs that are not allowed to be used during pregnancy (from FDA Pregnancy Categories D and X) were used. Irrational use of these drugs during pregnancy may result in different birth defects, as explained by thalidomide and diethylstilbestrol's tragedy. Knowledge of drug utilization and associated factors that affect the pattern is important to enhance rational prescribing. But information about prescription patterns and associated factors among pregnant women is scarce in the Debre Tabor area and generally in Ethiopia. This study was aimed at assessing drug prescription patterns, potential teratogenicity, and associated factors among pregnant women attending the antenatal care unit at Debre Tabor Comprehensive Specialized Hospital, Debre Tabor, Northwest Ethiopia. A retrospective cross-sectional study design was performed on 359 pregnant women attending antenatal care units from June 01, 2022, to August 30, 2022, in the hospital. Necessary data were obtained through a questionnaire by reviewing the medical charts of the women. Analysis of the data was performed using SPSS Version 23. The association of the independent variables to medication use was assessed using multivariate logistic regression. A value of less than 0.05 was considered significant. Most of the study participants (325/359) were married (90.5%). From a total of 359 participants, 350 (97.5%) were prescribed with drugs. About 64% (385/602) of the prescribed medications were iron and vitamins. The most commonly prescribed medications are iron and folic acid combination (340/602, 56.5%), albendazole (48/602, 8%), mebendazole (37/602, 6.1%), omeprazole (33/602, 5.5%), followed by amoxicillin (32/602, 5.3%). The majority (79.3%) of the drugs were from FDA Pregnancy Categories A and B. Prescribed drug utilization was more probable in women who first visited the facility at their second (AOR = 2.91, 95% CI [1.12-6.64]) and third trimesters (AOR = 4.32, 95% CI [1.37-6.81]), had chronic illness (AOR = 7.54, 95% CI [2.34-14.68]), and live in rural areas (AOR = 2.47, 95% CI [1.56-8.43]). The study revealed that the prescription pattern in the hospital is in line with the WHO reference. Age, gravidity, number of ANC visits, first visit to the facility, presence of chronic illness, educational status, and residency were significantly associated with prescription drug use in pregnant mothers. But still, some pregnant women received drugs that may have teratogenicity risk (FDA Category C).
约 80%的孕妇在怀孕期间至少使用一种药物。许多不允许在怀孕期间使用的药物（来自 FDA 妊娠类别 D 和 X）被使用。这些药物在怀孕期间的不合理使用可能会导致不同的出生缺陷，正如反应停和己烯雌酚的悲剧所解释的那样。了解药物的使用情况以及影响这种模式的相关因素对于增强合理处方至关重要。但是，关于孕妇用药模式和相关因素的信息在德布雷塔博尔地区和埃塞俄比亚普遍匮乏。本研究旨在评估在德布雷塔博尔综合专科医院产前护理单位就诊的孕妇的药物处方模式、潜在的致畸性和相关因素。在医院，于 2022 年 6 月 1 日至 2022 年 8 月 30 日期间，对 359 名参加产前护理单位的孕妇进行了回顾性横断面研究设计。通过审查妇女的病历，通过问卷调查获得必要的数据。使用 SPSS 版本 23 对数据进行分析。使用多变量逻辑回归评估独立变量与药物使用的关联。 值小于 0.05 被认为具有显著性。大多数研究参与者（325/359）已婚（90.5%）。在总共 359 名参与者中，有 350 名（350/359）被开了处方。约 64%（385/602）的处方药物为铁和维生素。最常开的药物是铁和叶酸合剂（340/602，56.5%）、阿苯达唑（48/602，8%）、甲苯咪唑（37/602，6.1%）、奥美拉唑（33/602，5.5%），其次是阿莫西林（32/602，5.3%）。大多数（79.3%）药物来自 FDA 妊娠类别 A 和 B。在首次在第二个（AOR = 2.91，95%CI [1.12-6.64]）和第三个三个月（AOR = 4.32，95%CI [1.37-6.81]）就诊的妇女、患有慢性病（AOR = 7.54，95%CI [2.34-14.68]）和居住在农村地区（AOR = 2.47，95%CI [1.56-8.43]）的妇女中，更有可能开处方药物。研究表明，该医院的处方模式符合世卫组织的参考标准。年龄、孕次、 ANC 就诊次数、首次就诊、慢性病、教育程度和居住地与孕妇用药显著相关。但仍有一些孕妇使用了可能具有致畸性风险的药物（FDA 类别 C）。
