Hasan Ghazwan Abdulla, Al-Obaidi Ahmed Dheyaa, Hashim Hashim Talib, Najah Al-Obaidi Mustafa, Al-Saady Yousif Ali, Othman Assalah, Khunda Sara S, Saab Omar, Al-Obaidi Hasan, Merza Nooraldin
Middle East Private Hospital, Baghdad, Iraq.
College of Medicine, University of Baghdad, Baghdad, Iraq.
Clin Med Insights Endocrinol Diabetes. 2024 Nov 17;17:11795514241300995. doi: 10.1177/11795514241300995. eCollection 2024.
Pre-diabetes, characterized by elevated glycemic indices, poses a high risk of diabetes development, and is increasingly linked to non-specific low back pain. While mechanisms remain incompletely understood, metabolic, inflammatory, and neurological factors are implicated. Dietary interventions, including low-glycemic and anti-inflammatory diets, alongside weight management, may improve outcomes in this population.
In this non-randomized controlled trial, we aim to evaluate the influence of decreasing HbA1c levels on reducing chronic non-specific low back pain in pre-diabetic, non-obese individuals, as well as emphasizing the importance of such a study in supporting the literature.
A non-randomized controlled single-blind clinical trial was conducted among 82 participants with chronic non-specific low back pain and pre-diabetes at an outpatient clinic in Baghdad from the 30th of January to the 22nd of September. The intervention methods aimed at reducing HbA1c levels to assess the reduction impact on alleviating chronic non-specific low back pain included dietary adjustments, sleep optimization, and correction of vitamins and minerals deficiencies. The follow-up process was conducted individually for each participant, with a monthly assessment over a period of six months.
At 12 weeks a significant decrease in chronic non-specific low back pain severity was observed in patients with lower HbA1C levels yielding a -value of .021. Similarly, at 24 weeks there was a decline in the number of patients who reported chronic non-specific low back pain, and the association to lower HbA1C levels was significant with a -value of .005.
This study suggests the presence of a statistically significant association between reduction of HbA1C levels and ensuing improvement in chronic non-specific low back pain symptoms in non-obese prediabetic patients.
糖尿病前期以血糖指数升高为特征，具有发展为糖尿病的高风险，并且越来越多地与非特异性腰痛相关联。虽然其机制尚未完全明确，但代谢、炎症和神经因素都与之有关。饮食干预，包括低血糖和抗炎饮食，以及体重管理，可能会改善这一人群的状况。
在这项非随机对照试验中，我们旨在评估降低糖化血红蛋白（HbA1c）水平对减轻糖尿病前期非肥胖个体慢性非特异性腰痛的影响，并强调此类研究对支持相关文献的重要性。
1月30日至9月22日，在巴格达的一家门诊诊所，对82名患有慢性非特异性腰痛和糖尿病前期的参与者进行了一项非随机对照单盲临床试验。干预方法旨在降低HbA1c水平，以评估其对缓解慢性非特异性腰痛的减轻影响，包括饮食调整、优化睡眠以及纠正维生素和矿物质缺乏。对每位参与者进行单独随访，在六个月的时间内每月进行一次评估。
在12周时，HbA1C水平较低的患者慢性非特异性腰痛严重程度显著降低，P值为0.021。同样，在24周时，报告慢性非特异性腰痛的患者数量有所下降，与较低HbA1C水平的关联显著，P值为0.005。
本研究表明，在非肥胖糖尿病前期患者中，HbA1C水平的降低与慢性非特异性腰痛症状随后的改善之间存在统计学上的显著关联。
