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肝结节病:一例报告及文献综述

Hepatic Sarcoidosis: A Case Report and Literature Review.

作者信息

Zaher Eli A, Ebrahim Mohamed A, Patel Parth

机构信息

Internal Medicine, Ascension Saint Joseph Hospital, Chicago, USA.

出版信息

Cureus. 2024 Oct 19;16(10):e71873. doi: 10.7759/cureus.71873. eCollection 2024 Oct.

Abstract

Sarcoidosis is a granulomatous disease that can affect multiple organs, including the liver. We present a case of a 43-year-old male with hepatic sarcoidosis who presented with jaundice and pruritus. Laboratory findings showed mixed hyperbilirubinemia and elevated liver enzymes. Imaging revealed mediastinal lymphadenopathy and diffuse liver changes, raising suspicion for sarcoidosis. Elevated angiotensin-converting enzyme (ACE) levels and a liver biopsy confirmed the diagnosis. The patient was treated with ursodeoxycholic acid, leading to symptomatic improvement. This case highlights the importance of recognizing hepatic involvement in sarcoidosis and the potential role of ursodeoxycholic acid in its management.

摘要

结节病是一种可累及包括肝脏在内多个器官的肉芽肿性疾病。我们报告一例43岁男性肝结节病患者,该患者表现为黄疸和瘙痒。实验室检查结果显示混合性高胆红素血症和肝酶升高。影像学检查发现纵隔淋巴结肿大和肝脏弥漫性改变,增加了结节病的可疑性。血管紧张素转换酶(ACE)水平升高及肝脏活检确诊了该病。患者接受熊去氧胆酸治疗后症状改善。该病例突出了认识结节病肝脏受累情况的重要性以及熊去氧胆酸在其治疗中的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1297/11573004/49564df824ad/cureus-0016-00000071873-i02.jpg

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