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残角子宫非交通性妊娠中的异位妊娠:成功药物治疗1例及文献复习

Ectopic Pregnancy in a Non-communicating Rudimentary Uterine Horn: A Case of Successful Medical Management and Literature Review.

作者信息

Harpey Amelie M, McNierney Bridget P, O'Connell Alexis A, Lingo Emily G, Wood Ellen G

机构信息

Obstetrics and Gynecology, Philadelphia College of Osteopathic Medicine, Philadelphia, USA.

Obstetrics and Gynecology, Hospital Corporation of America (HCA) East Florida, Fort Lauderdale, USA.

出版信息

Cureus. 2024 Oct 19;16(10):e71856. doi: 10.7759/cureus.71856. eCollection 2024 Oct.

DOI:10.7759/cureus.71856
PMID:39559660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11572001/
Abstract

A non-communicating rudimentary uterine horn is a Müllerian abnormality that manifests due to abnormal Müllerian duct development. This abnormality is associated with endometriosis, infertility, and pregnancy complications, including ectopic pregnancy, abnormal fetal presentation, abruption, increased fetal mortality and morbidity, preterm rupture of membranes, preterm birth, intrauterine growth restriction, and uterine rupture. If pregnancy does occur, there is a high risk of complications, most notably rupture of the rudimentary horn. For this reason, such pregnancies are managed similarly to an ectopic pregnancy with either administration of methotrexate, laparoscopic removal, or a combination of both. This article describes a case of a pregnancy in a previously diagnosed, non-communicating rudimentary uterine horn that was managed medically. We aim to explore the need for early identification of rudimentary uterine horns and the management of pregnancy in these individuals.

摘要

非交通性残角子宫是一种苗勒管异常,由于苗勒管发育异常而表现出来。这种异常与子宫内膜异位症、不孕和妊娠并发症有关,包括异位妊娠、胎位异常、胎盘早剥、胎儿死亡率和发病率增加、胎膜早破、早产、胎儿宫内生长受限和子宫破裂。如果确实发生妊娠,并发症风险很高,最显著的是残角子宫破裂。因此,此类妊娠的处理方式与异位妊娠相似,可采用甲氨蝶呤治疗、腹腔镜切除或两者结合。本文描述了一例先前诊断为非交通性残角子宫的妊娠病例,该病例采用药物治疗。我们旨在探讨早期识别残角子宫的必要性以及这些个体妊娠的管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/1119549e4ce4/cureus-0016-00000071856-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/5280021c8a0b/cureus-0016-00000071856-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/f066c767376b/cureus-0016-00000071856-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/5a03546f60fe/cureus-0016-00000071856-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/d91cf804b931/cureus-0016-00000071856-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/1119549e4ce4/cureus-0016-00000071856-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/5280021c8a0b/cureus-0016-00000071856-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/f066c767376b/cureus-0016-00000071856-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/5a03546f60fe/cureus-0016-00000071856-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/d91cf804b931/cureus-0016-00000071856-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8c0/11572001/1119549e4ce4/cureus-0016-00000071856-i05.jpg

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本文引用的文献

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Surgical management of an ectopic pregnancy in the setting of an unexpected Müllerian anomaly: intraoperative and postoperative implications.在意外 Müllerian 异常情况下异位妊娠的手术处理:术中及术后的影响。
Fertil Steril. 2024 Nov;122(5):951-953. doi: 10.1016/j.fertnstert.2024.07.036. Epub 2024 Jul 30.
2
Abdominal pregnancy secondary to uterine horn pregnancy: a case report.子宫角妊娠致腹腔妊娠 1 例报告
BMC Pregnancy Childbirth. 2023 Jun 3;23(1):412. doi: 10.1186/s12884-023-05704-4.
3
Laparoscopic Management of an Advanced Nonruptured Ectopic Pregnancy in a Rudimentary Uterine Horn.
腹腔镜治疗残角子宫中晚期未破裂异位妊娠
J Minim Invasive Gynecol. 2023 Mar;30(3):169-170. doi: 10.1016/j.jmig.2022.12.004. Epub 2022 Dec 9.
4
Ultrasonographic features of the endometrium following successful medical termination of early pregnancy.早期妊娠药物流产后子宫内膜的超声特征。
Eur J Obstet Gynecol Reprod Biol. 2023 Jan;280:102-107. doi: 10.1016/j.ejogrb.2022.11.018. Epub 2022 Nov 25.
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ASRM müllerian anomalies classification 2021.美国生殖医学学会 Müllerian 畸形分类 2021 版
Fertil Steril. 2021 Nov;116(5):1238-1252. doi: 10.1016/j.fertnstert.2021.09.025.
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Drugs used to induce fetal demise prior to abortion: a systematic review.堕胎前用于导致胎儿死亡的药物:一项系统评价
Contracept X. 2020 Nov 9;2:100046. doi: 10.1016/j.conx.2020.100046. eCollection 2020.
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Successful management of a rudimentary uterine horn ectopic pregnancy by combining methotrexate and surgery: A case report.甲氨蝶呤联合手术成功治疗残角子宫异位妊娠:一例报告
Case Rep Womens Health. 2019 Oct 31;24:e00158. doi: 10.1016/j.crwh.2019.e00158. eCollection 2019 Oct.
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The pregnancy outcomes of patients with rudimentary uterine horn: A 30-year experience.残角子宫患者的妊娠结局:30 年经验。
PLoS One. 2019 Jan 25;14(1):e0210788. doi: 10.1371/journal.pone.0210788. eCollection 2019.
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ACOG Practice Bulletin No. 191: Tubal Ectopic Pregnancy.美国妇产科医师学会临床实践公告第 191 号:输卵管妊娠。
Obstet Gynecol. 2018 Feb;131(2):e65-e77. doi: 10.1097/AOG.0000000000002464.
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An autopsy report on a ruptured rudimentary horn (uterine anomaly) with ectopic pregnancy.一份关于破裂的残角子宫(子宫畸形)伴异位妊娠的尸检报告。
Forensic Sci Int. 2013 Jan 10;224(1-3):e4-6. doi: 10.1016/j.forsciint.2012.10.019. Epub 2012 Dec 20.