González Silvia A, Affranchino José L
Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales, Universidad de Belgrano (UB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Centro de Virología Humana y Animal (CEVHAN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Abierta Interamericana (UAI), Buenos Aires, Argentina.
Virology. 2025 Jan;601:110304. doi: 10.1016/j.virol.2024.110304. Epub 2024 Nov 16.
Feline immunodeficiency virus (FIV) is a retrovirus of worldwide distribution that can cause an acquired immunodeficiency disease in domestic cats. FIV and the primate lentiviruses, human and simian immunodeficiency viruses (HIV and SIV, respectively) share structural and biological features but also exhibit important differences, which reflect both their evolutionary relationship and divergence. Given that FIV is not only an important cat pathogen but also a useful model for certain aspects of HIV-1 infections in humans, the study of FIV biology is highly relevant. In this review we provide an updated description of the molecular mechanisms involved in each stage of the FIV life cycle.
猫免疫缺陷病毒（FIV）是一种分布于全球的逆转录病毒，可在家猫中引发一种获得性免疫缺陷疾病。FIV与灵长类慢病毒，即人类免疫缺陷病毒和猴免疫缺陷病毒（分别为HIV和SIV），具有结构和生物学特征，但也存在重要差异，这既反映了它们的进化关系，也体现了它们的分化。鉴于FIV不仅是一种重要的猫病原体，也是人类HIV-1感染某些方面的有用模型，对FIV生物学的研究具有高度相关性。在本综述中，我们对FIV生命周期各阶段所涉及的分子机制进行了更新描述。
