Chang M N, O'Brien P C
Control Clin Trials. 1986 Mar;7(1):18-26. doi: 10.1016/0197-2456(86)90004-8.
A procedure is proposed for obtaining confidence intervals for the probability of response following completion of a group sequential phase II trial. Numerical examples showed that, by ordering the sample space using the likelihood principle, we are able to shorten the length of the intervals and to obtain more accurate coverage of probability relative to previously proposed methods. The method may also be used for interval estimation following phase III trials.
