Wilkinson J D, Pollack M M, Ruttimann U E, Glass N L, Yeh T S
Crit Care Med. 1986 Apr;14(4):271-4. doi: 10.1097/00003246-198604000-00002.
The association of multiple organ system failure (MOSF) with mortality was investigated in 831 consecutive admissions to a pediatric ICU. The incidence of MOSF (at least two organ system failures, OSF) was 27%. Of the 62 nonsurvivors, 60 (97%) had MOSF. The mortality for patients with MOSF was 54%, compared to a mortality of 0.3% for patients without MOSF. Mortality increased directly with increasing number of OSF (p less than .0001). The mortality was 1% for one OSF, 11% for two OSF, 50% for three OSF, and 75% for four OSF. Comparison of these results with data from adult ICU patients indicates that the mortality and clinical course of MOSF in children is distinct from adults. MOSF is significantly associated with mortality in pediatric patients; however, it is not sufficiently discriminating to determine continuation or withdrawal of ICU support.
在一家儿科重症监护病房（ICU）连续收治的831例患者中，对多器官系统衰竭（MOSF）与死亡率之间的关联进行了调查。MOSF（至少两个器官系统衰竭，OSF）的发生率为27%。在62例死亡患者中，60例（97%）发生了MOSF。发生MOSF的患者死亡率为54%，而未发生MOSF的患者死亡率为0.3%。死亡率随OSF数量的增加而直接上升（p<0.0001）。一个OSF的死亡率为1%，两个OSF为11%，三个OSF为50%，四个OSF为75%。将这些结果与成人ICU患者的数据进行比较表明，儿童MOSF的死亡率和临床病程与成人不同。MOSF在儿科患者中与死亡率显著相关；然而，它在确定是否继续或停止ICU支持方面的区分能力不足。
