Cook C S, Grubb B
Curr Eye Res. 1986 Feb;5(2):171-3. doi: 10.3109/02713688609015106.
Rabbits were continuously administered copper sulfate via subcutaneously implanted osmotic pumps. After one month, plasma, liver, ocular tissues and fluids were analyzed for copper by atomic absorption spectrophotometry. No elevation in copper content of the ocular fluids, lens or iris was noted although, dose-related increases were seen in the plasma and liver indicating that the copper was absorbed and disseminated systemically. It is likely that excess copper, like that which is normally ingested and absorbed, is largely protein-bound in the circulation, preventing crossing of the blood-ocular barrier.
通过皮下植入渗透泵持续给兔子注射硫酸铜。一个月后，用原子吸收分光光度法分析血浆、肝脏、眼组织和眼内液中的铜含量。尽管血浆和肝脏中的铜含量出现了与剂量相关的增加，表明铜已被吸收并在全身扩散，但眼内液、晶状体或虹膜中的铜含量并未升高。很可能过量的铜，就像正常摄入和吸收的铜一样，在循环中主要与蛋白质结合，从而阻止其穿过血眼屏障。
