Research Service, VA Boston Healthcare System, Boston, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Adv Neurobiol. 2024;40:321-349. doi: 10.1007/978-3-031-69491-2_12.
This chapter is a selective and critical review of the literature on gamma oscillations in schizophrenia and related studies in other relevant fields that pertain to the hypothesis that abnormal gamma oscillations underlie symptoms of psychosis in individuals with schizophrenia. These gamma abnormalities result from deficient recurrent inhibition, in which parvalbumin-expressing, fast-spiking inhibitory interneurons do not receive sufficient excitation from N-methyl-D-aspartate receptors, resulting in a loss of phasic control over pyramidal cell spiking and impairment of gamma generation. The evidence for this hypothesis is critically reviewed, focusing on studies in the areas of visual feature binding, auditory steady-state response, and spontaneous gamma activity. The current state of the field is discussed, and recommendations for future directions are presented.
这一章是对精神分裂症中γ 振荡的文献以及其他相关领域的相关研究进行的选择性和批判性回顾，这些研究与以下假设有关：精神分裂症个体的精神病症状是由异常的γ 振荡引起的。这些γ 异常是由于缺乏重复抑制引起的，其中表达 parvalbumin 的快速放电抑制性中间神经元不能从 N-甲基-D-天冬氨酸受体获得足够的兴奋，导致对锥体细胞放电的相位控制丧失和γ 生成受损。批判性地回顾了这一假设的证据，重点是在视觉特征绑定、听觉稳态反应和自发γ 活动等领域的研究。讨论了该领域的现状，并提出了未来的发展方向。
