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自闭症谱系障碍儿童与正常发育儿童的听觉稳态反应无差异。

No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children.

机构信息

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.

Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

出版信息

J Autism Dev Disord. 2024 May;54(5):1947-1960. doi: 10.1007/s10803-023-05907-w. Epub 2023 Mar 17.

Abstract

Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6-17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported.

摘要

听觉稳态响应(ASSR)已被研究作为自闭症谱系障碍(ASD)中异常听觉感觉处理的潜在生物标志物,但其结果存在差异。受先前体感研究结果的启发,即 ASD 个体与典型发育(TD)个体之间在稳态刺激频率的两倍处的试验间相干性(ITC)存在组间差异,我们使用脑磁图检查了分别在 25 和 50 以及 43 和 86 Hz 下对 25-Hz 和 43-Hz 听觉刺激的 ASSR。数据来自 22 名 ASD 和 31 名 TD 儿童,年龄在 6-17 岁之间。ITC 测量结果表明,在刺激和双频处均存在明显的 ASSR,但组间无显著差异。这些结果不支持 ASSR 作为 ASD 中异常听觉处理的可靠生物标志物。此外,先前观察到的 ASD 中异常的双频体感反应并没有推广到听觉模式。因此,关于 ASD 中存在模态独立的异常局部连通性的假设没有得到支持。

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