Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Straße 25, 07743, Jena, Germany.
Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany.
Sci Rep. 2024 Nov 19;14(1):28581. doi: 10.1038/s41598-024-79575-w.
The association of serum concentrations of minerals and phosphate with overall and cardiovascular mortality based on renal function is poorly understood. 3307 patients (average age 62.7 ± 10.6 years) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study were grouped by estimated glomerular filtration rate (eGFR) into three categories: < 60, 60-89, and ≥ 90 mL/min per 1.73 m, per KDIGO 2022 guidelines and were analysed using Cox regression. Low serum sodium and iron concentrations were associated with poor renal function and increased overall mortality risk, whereas higher serum zinc concentrations were associated with reduced overall and cardiovascular mortality risk. Elevated serum copper concentrations were associated with increased mortality risk across all eGFR categories. Comparing low and normal eGFR, we observed a fourfold increase in all-cause mortality risk for eGFR < 60 mL/min per 1.73 m and a twofold increase for eGFR 60-89 mL/min per 1.73 m, accompanied by changes in serum mineral concentrations. The optimal range of mineral and phosphate concentrations in serum was strongly related to renal function. To reduce mortality risk, it's important to regularly monitor serum mineral and phosphate concentrations as well as renal function, especially in cardiovascular patients with compromised renal function.
基于肾功能，血清矿物质和磷酸盐浓度与全因和心血管死亡率的相关性尚未得到充分了解。3307 名（平均年龄 62.7±10.6 岁）来自路德维希港风险和心血管健康（LURIC）研究的患者，根据估算肾小球滤过率（eGFR）分为三组：<60、60-89 和≥90 mL/min per 1.73 m2，按照 KDIGO 2022 指南进行分组，并使用 Cox 回归进行分析。血清钠和铁浓度低与肾功能差和全因死亡率增加相关，而血清锌浓度高与全因和心血管死亡率降低相关。血清铜浓度升高与所有 eGFR 类别中的死亡率风险增加相关。与低 eGFR 和正常 eGFR 相比，我们观察到 eGFR<60 mL/min per 1.73 m2 的全因死亡率风险增加了四倍，eGFR 60-89 mL/min per 1.73 m2 的全因死亡率风险增加了两倍，同时伴有血清矿物质浓度的变化。血清矿物质和磷酸盐浓度的最佳范围与肾功能密切相关。为了降低死亡率风险，定期监测血清矿物质和磷酸盐浓度以及肾功能非常重要，尤其是在肾功能受损的心血管病患者中。
