经皮内窥镜下腰椎间盘切除术(PELD)联合脊神经根消融术与单纯 PELD 治疗腰椎间盘突出症腰痛的疗效比较。

Efficacy of percutaneous endoscopic lumbar discectomy (PELD) combined with sinuvertebral nerve ablation versus PELD for low back pain in lumbar disc herniation.

机构信息

Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Beijing University of Chinese Medicine, Beijing, China.

出版信息

J Orthop Surg Res. 2024 Nov 19;19(1):769. doi: 10.1186/s13018-024-05269-8.

Abstract

BACKGROUND

Percutaneous endoscopic lumbar discectomy (PELD) has demonstrated variable efficacy in alleviating low back pain (LBP) associated with lumbar disc herniation (LDH). Sinuvertebral nerve ablation (SNA), which targets the nociceptive pathway implicated in discogenic LBP pathogenesis, has emerged as a potential adjunctive therapy. The efficacy of endoscopic radiofrequency ablation in enhancing PELD for the treatment of LBP in patients with LDH remains unclear.

METHODS

A retrospective cohort study was conducted on LDH patients with concomitant LBP treated at the Spinal Surgery Department, China-Japan Friendship Hospital, from June 2020 to June 2023. Participants were categorized into two groups: PELD combined with SNA (n = 51) and PELD alone (n = 46). Primary outcome measures included the Visual Analog Scale (VAS) for pain, the Japanese Orthopaedic Association (JOA) score, and the Oswestry Disability Index (ODI) at baseline and 1-, 3-, and 6-month follow-ups.

RESULTS

Both groups exhibited significant improvements in VAS, JOA, and ODI scores for LBP and leg pain postoperatively compared to preoperative assessments. Notably, the PELD combined with SNA group demonstrated statistically significant superior outcomes in VAS, JOA, and ODI scores specifically for LBP compared to the PELD group.

CONCLUSION

The combination of PELD with SNA significantly improves LBP outcomes compared to PELD alone in LDH patients. While the observed improvements did not reach the minimal clinically important differences (MICD), these findings suggest that SNA may enhance the efficacy of PELD in LBP management.

摘要

背景

经皮内镜腰椎间盘切除术(PELD)已被证明在缓解与腰椎间盘突出症(LDH)相关的腰痛(LBP)方面具有不同的疗效。针对椎间盘源性 LBP 发病机制中牵涉痛途径的脊神经根消融术(SNA)已成为一种潜在的辅助治疗方法。内镜射频消融术增强 PELD 治疗 LDH 患者 LBP 的疗效尚不清楚。

方法

对 2020 年 6 月至 2023 年 6 月在中国中日友好医院脊柱外科接受治疗的伴发 LBP 的 LDH 患者进行回顾性队列研究。参与者分为两组:PELD 联合 SNA(n=51)和 PELD 单独治疗(n=46)。主要观察指标包括基线、术后 1、3 和 6 个月时的疼痛视觉模拟评分(VAS)、日本矫形协会(JOA)评分和 Oswestry 残疾指数(ODI)。

结果

两组患者术后 LBP 和腿痛的 VAS、JOA 和 ODI 评分均较术前显著改善。值得注意的是,与 PELD 组相比,PELD 联合 SNA 组在 LBP 方面的 VAS、JOA 和 ODI 评分具有统计学上的显著优势。

结论

与单独 PELD 相比,PELD 联合 SNA 可显著改善 LDH 患者的 LBP 预后。虽然观察到的改善未达到最小临床重要差异(MICD),但这些发现表明 SNA 可能增强 PELD 在 LBP 管理中的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3169/11575413/75fa7b42e110/13018_2024_5269_Fig1_HTML.jpg

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