Liu Xinyu, Yuan Suomao, Tian Yonghao, Wang Lianlei, Gong Liangtai, Zheng Yanping, Li Jianmin
J Neurosurg Spine. 2018 Mar;28(3):317-325. doi: 10.3171/2017.6.SPINE172. Epub 2018 Jan 5.
OBJECTIVE This study aimed to evaluate the clinical outcomes of percutaneous endoscopic transforaminal discectomy (PETD), microendoscopic discectomy (MED), and microdiscectomy (MD) for treatment of symptomatic lumbar disc herniation (LDH). METHODS One hundred ninety-two patients with symptomatic LDH at L3-4 and L4-5 were included in this study. The mean (± SD) age of patients was 34.2 ± 2.6 years (range 18-62 years). The patients were divided into groups as follows: group A was treated with PETD and included 60 patients (31 men and 29 women) with a mean age of 36.2 years; group B was treated with MED and included 63 patients (32 men and 31 women) with a mean age of 33.1 years; and group C was treated with MD and included 69 patients (36 men and 33 women) with a mean age of 34.0 years. The Japanese Orthopaedic Association (JOA) scale for low-back pain (LBP), Oswestry Disability Index (ODI), creatine phosphokinase activity 3 days after surgery, and visual analog scale (VAS) scores for LBP and leg pain were used for evaluation of clinical results. RESULTS There were no significant differences in mean preoperative JOA score, ODI score, and VAS scores for LBP and leg pain among groups A, B, and C. Incision length, duration of the operation, blood loss, creatine phosphokinase, length of hospital stay, and postoperative incision pain according to the VAS were best in the PETD group (p < 0.05). The number of seconds of intraoperative fluoroscopy was highest in the PETD group (p < 0.05), whereas there was no difference between the MED and MD groups. Three cases from the MED group and 2 cases from the MD group had an intraoperative durotomy. No CSF leakage was observed after surgery. One case from the MED group and 3 cases from the MD group had incision infections. There were no neurological deficits related to the surgeries in any of the groups. Fifty-five (91.6%), 59 (93.7%), and 62 patients (89.9%) had at least 2 years of follow-up in groups A, B, and C, respectively. At the last follow-up, JOA scores, VAS scores of LBP and leg pain, and ODI scores were significantly better than preoperative correlates in all groups. There were no differences among the 3 groups in JOA scores, JOA recovery rate, ODI scores, and VAS scores for leg pain. The VAS score for LBP was best in the PETD group (p < 0.05). No lumbar instability was observed in any group. Three cases (5.5%) in the PETD group had recurrent LDH, and 2 recurrent cases (3.4%) were confirmed in the MED group. CONCLUSIONS PETD, MED, and MD were all reliable techniques for the treatment of symptomatic LDH. With a restricted indication, PETD can result in rapid recovery and better clinical results after at least 2 years of follow-up.
目的 本研究旨在评估经皮内镜下经椎间孔椎间盘切除术(PETD)、显微内镜下椎间盘切除术(MED)和显微椎间盘切除术(MD)治疗症状性腰椎间盘突出症(LDH)的临床疗效。方法 本研究纳入192例L3 - 4和L4 - 5节段症状性LDH患者。患者的平均(±标准差)年龄为34.2±2.6岁(范围18 - 62岁)。患者分为以下几组:A组采用PETD治疗,包括60例患者(31例男性和29例女性),平均年龄36.2岁;B组采用MED治疗,包括63例患者(32例男性和31例女性),平均年龄33.1岁;C组采用MD治疗,包括69例患者(36例男性和33例女性),平均年龄34.0岁。采用日本骨科学会(JOA)下腰痛(LBP)量表、Oswestry功能障碍指数(ODI)、术后3天的肌酸磷酸激酶活性以及LBP和腿痛的视觉模拟量表(VAS)评分来评估临床结果。结果 A、B、C组术前JOA评分、ODI评分以及LBP和腿痛的VAS评分均值无显著差异。PETD组的切口长度、手术时间、失血量、肌酸磷酸激酶、住院时间以及根据VAS评估的术后切口疼痛情况最佳(p < 0.05)。PETD组术中透视时间最长(p < 0.05),而MED组和MD组之间无差异。MED组有3例和MD组有2例术中出现硬脊膜切开。术后未观察到脑脊液漏。MED组有1例和MD组有3例发生切口感染。所有组均未出现与手术相关的神经功能缺损。A、B、C组分别有55例(91.6%)、59例(93.7%)和62例(89.9%)患者至少随访了2年。在最后一次随访时,所有组的JOA评分、LBP和腿痛的VAS评分以及ODI评分均显著优于术前。三组在JOA评分、JOA恢复率、ODI评分以及腿痛的VAS评分方面无差异。PETD组LBP的VAS评分最佳(p < 0.05)。所有组均未观察到腰椎不稳。PETD组有3例(5.5%)出现复发性LDH,MED组确诊2例复发病例(3.4%)。结论 PETD、MED和MD都是治疗症状性LDH的可靠技术。在适应证受限的情况下,PETD至少随访2年后可实现快速康复并取得更好的临床效果。