Extracellular vesicle production by oral bacteria related to dental caries and periodontal disease: role in microbe-host and interspecies interactions.

Extracellular vesicles (EVs) are cell membrane-derived structures between 20-400 nm in size. In bacteria, EVs play a crucial role in molecule secretion, cell wall biogenesis, cell-cell communication, biofilm development, and host-pathogen interactions. Despite these increasing reports of bacterial-derived vesicles, there remains a limited number of studies that summarize oral bacterial EVs, their cargo, and their main biological functions. Therefore, the aim of this review is to present the latest research on oral bacteria-derived EVs and how they can modulate various physiological and pathological processes in the oral cavity, including the pathogenesis of highly relevant diseases such as dental caries and periodontitis and their systemic complications. Overall, caries-associated bacteria (such as ) as well as periodontal pathogens (including the red complex pathogens , , and ) have all been shown to produce EVs that carry an array of virulent factors and molecules involved in biofilm and immune modulation, bacterial adhesion, and extracellular matrix degradation. As bacterial EV production is strongly impacted by genotypic and environmental variations, the inhibition of EV genesis and secretion remains a key potential future approach against oral diseases.