Cho I, Bertoni J M, Hopkins L
Drug Intell Clin Pharm. 1986 Mar;20(3):223-4. doi: 10.1177/106002808602000310.
Severe myoclonus, generalized seizures, and marked stupor occurred in a 39-year-old woman with chronic renal insufficiency after one week of moxalactam 2 g iv q8h. Moxalactam serum levels far exceeded the recommended therapeutic range. The drug half-life was 17 hours (normal 1.9). Excessively high levels of moxalactam, which penetrates the blood-brain-barrier relatively easily, may provoke seizures and encephalopathy.
