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肺祖细胞的自体移植为支气管扩张症的治疗带来了新的可能。

Autologous transplantation of lung progenitor cells comes into reality for bronchiectasis.

机构信息

Department of Allergy and Clinical Immunology, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, Guangzhou 510120, P.R. China; Guangzhou National Laboratory, Guangzhou, Guangdong 510005, P.R. China.

Department of Allergy and Clinical Immunology, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, Guangzhou 510120, P.R. China; Guangzhou National Laboratory, Guangzhou, Guangdong 510005, P.R. China.

出版信息

Cell Rep Med. 2024 Nov 19;5(11):101821. doi: 10.1016/j.xcrm.2024.101821.

DOI:10.1016/j.xcrm.2024.101821
PMID:39566465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11604412/
Abstract

Stem and progenitor cell-based regenerative therapies have the potential to cure chronic respiratory diseases. Yan et al. reported a clinical trial of autologous P63 progenitor cell transplantation in bronchiectasis patients, highlighting autologous transplantation of P63 progenitor cells as a novel candidate therapeutic option to improve pulmonary gas exchange function and quality of life.

摘要

基于干细胞和祖细胞的再生疗法有可能治愈慢性呼吸系统疾病。Yan 等人报告了一项关于支气管扩张症患者自体 P63 祖细胞移植的临床试验,强调了自体 P63 祖细胞移植作为改善肺气体交换功能和生活质量的一种新的候选治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3742/11604412/ed7854545498/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3742/11604412/ed7854545498/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3742/11604412/ed7854545498/gr1.jpg

相似文献

1
Autologous transplantation of lung progenitor cells comes into reality for bronchiectasis.肺祖细胞的自体移植为支气管扩张症的治疗带来了新的可能。
Cell Rep Med. 2024 Nov 19;5(11):101821. doi: 10.1016/j.xcrm.2024.101821.
2
Autologous transplantation of P63 lung progenitor cells in patients with bronchiectasis: A randomized, single-blind, controlled trial.支气管扩张症患者中 P63 肺祖细胞的自体移植:一项随机、单盲、对照试验。
Cell Rep Med. 2024 Nov 19;5(11):101819. doi: 10.1016/j.xcrm.2024.101819.
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Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis: a phase 1 clinical trial.自体P63+肺祖细胞移植治疗特发性肺纤维化:一项1期临床试验
Elife. 2025 Mar 4;13:RP102451. doi: 10.7554/eLife.102451.
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Regeneration of functional alveoli by adult human SOX9 airway basal cell transplantation.成体人 SOX9 气道基底细胞移植再生功能性肺泡。
Protein Cell. 2018 Mar;9(3):267-282. doi: 10.1007/s13238-018-0506-y. Epub 2018 Jan 17.
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Autologous transplantation of P63 lung progenitor cells for chronic obstructive pulmonary disease therapy.自体移植 P63 肺祖细胞治疗慢性阻塞性肺疾病。
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Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits.内皮祖细胞自体移植减轻兔急性肺损伤。
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本文引用的文献

1
Autologous transplantation of P63 lung progenitor cells in patients with bronchiectasis: A randomized, single-blind, controlled trial.支气管扩张症患者中 P63 肺祖细胞的自体移植:一项随机、单盲、对照试验。
Cell Rep Med. 2024 Nov 19;5(11):101819. doi: 10.1016/j.xcrm.2024.101819.
2
Bronchiectasis management in adults: state of the art and future directions.成人支气管扩张症的管理:现状和未来方向。
Eur Respir J. 2024 Jun 28;63(6). doi: 10.1183/13993003.00518-2024. Print 2024 Jun.
3
Autologous transplantation of P63 lung progenitor cells for chronic obstructive pulmonary disease therapy.
自体移植 P63 肺祖细胞治疗慢性阻塞性肺疾病。
Sci Transl Med. 2024 Feb 14;16(734):eadi3360. doi: 10.1126/scitranslmed.adi3360.
4
Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators.囊性纤维化肺部上皮干细胞变体的炎症活性不能被 CFTR 调节剂解决。
Am J Respir Crit Care Med. 2023 Nov 1;208(9):930-943. doi: 10.1164/rccm.202305-0818OC.
5
Stem cells and lung regeneration.干细胞与肺脏再生。
Am J Physiol Cell Physiol. 2020 Oct 1;319(4):C675-C693. doi: 10.1152/ajpcell.00036.2020. Epub 2020 Aug 12.
6
Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis.COPD 肺中的再生性化生克隆驱动炎症和纤维化。
Cell. 2020 May 14;181(4):848-864.e18. doi: 10.1016/j.cell.2020.03.047. Epub 2020 Apr 15.
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Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity.支气管扩张症的研究进展:表型分型、遗传学、微生物组学和疾病异质性。
Lancet. 2018 Sep 8;392(10150):880-890. doi: 10.1016/S0140-6736(18)31767-7.
8
Regeneration of functional alveoli by adult human SOX9 airway basal cell transplantation.成体人 SOX9 气道基底细胞移植再生功能性肺泡。
Protein Cell. 2018 Mar;9(3):267-282. doi: 10.1007/s13238-018-0506-y. Epub 2018 Jan 17.
9
Cell therapy for lung disease.用于治疗肺部疾病的细胞疗法。
Eur Respir Rev. 2017 Jun 28;26(144). doi: 10.1183/16000617.0044-2017. Print 2017 Jun 30.
10
p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.p63(阳性)Krt5(阳性)的远端气道干细胞对肺再生至关重要。
Nature. 2015 Jan 29;517(7536):616-20. doi: 10.1038/nature13903. Epub 2014 Nov 12.