The Faculty of Medicine, Duy Tan University, Da Nang, 550000, Vietnam.
University of Medicine and Pharmacy, Hue University, Hue, 530000, Vietnam.
Sci Rep. 2024 Nov 21;14(1):28816. doi: 10.1038/s41598-024-78182-z.
Erectile dysfunction (ED) shares common risk factors with cardiovascular (CV) disease, such as a sedentary lifestyle, obesity, and metabolic syndrome. However, the relationship between ED and CV risk in Vietnam remains unknown. To investigate this, we conducted a multi-center observational study, randomly selecting 2,936 men aged 40 to 69 years in Vietnam, with 385 participants included after exclusions. The study evaluated the 10-year CV risk using the Systematic Coronary Risk Evaluation 2-Diabetes (SCORE2-Diabetes) score and assessed ED using the International Index of Erectile Function (IIEF-5) score. Results showed that men with diabetes mellitus and hypertension had significantly lower IIEF-5 scores compared to healthy individuals (18 [15-22] vs. 23 [20-24], p < 0.001). Additionally, the IIEF-5 score proved effective in identifying patients at very high CV risk, with an area under the curve (AUC) of 0.747, a cutoff point of 18.5, sensitivity of 69.6%, and specificity of 69.9%. Furthermore, we found a significant inverse correlation between SCORE2-Diabetes and IIEF-5 (ρ = -0.45 and p < 0.001). These findings establish a significant connection between ED and CV risk in men with diabetes, underscoring the need for integrated screening and management strategies to address both conditions concurrently.
勃起功能障碍（ED）与心血管（CV）疾病有共同的危险因素，如久坐不动的生活方式、肥胖和代谢综合征。然而，ED 与越南 CV 风险之间的关系尚不清楚。为了研究这一点，我们进行了一项多中心观察性研究，在越南随机选择了 2936 名年龄在 40 至 69 岁的男性，排除后有 385 名参与者入选。该研究使用系统性冠状动脉风险评估 2-糖尿病（SCORE2-糖尿病）评分评估 10 年 CV 风险，并使用国际勃起功能指数（IIEF-5）评分评估 ED。结果表明，与健康个体相比，患有糖尿病和高血压的男性 IIEF-5 评分明显较低（18 [15-22] 与 23 [20-24]，p<0.001）。此外，IIEF-5 评分在识别 CV 风险极高的患者方面非常有效，曲线下面积（AUC）为 0.747，截断值为 18.5，灵敏度为 69.6%，特异性为 69.9%。此外，我们发现 SCORE2-糖尿病与 IIEF-5 之间存在显著的负相关（ρ=-0.45，p<0.001）。这些发现表明，在患有糖尿病的男性中，ED 与 CV 风险之间存在显著关联，强调需要综合筛查和管理策略来同时解决这两种情况。
