Zhang Yu Qiao, Zhang Xiu Juan, Shen Ru Yue, Zhang Yuzhou, Tang Fang Yao, Szeto Simon K H, Ng Danny Siu-Chun, Kam Ka Wai, Young Alvin L, Chen Li Jia, Pang Chi Pui, Tham Clement C, Yam Jason C, Chan Poemen P
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong SAR, China.
Department of Ophthalmology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Eye Vis (Lond). 2024 Nov 2;11(1):47. doi: 10.1186/s40662-024-00411-3.
To investigate the impact of optic disc torsion (ODT), horizontal disc tilt (HDT) angle, and ovality index (OI) on different retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) segments in healthy myopic eyes.
ODT and OI were measured from fundus photographs. HDT angle, peripapillary RNFL, and macular GCIPL were measured by swept-source optical coherence tomography (SS-OCT). The association between optic disc morphology and the RNFL/GCIPL thickness were evaluated, with age and axial length (AL) adjusted.
Among 530 healthy myopic eyes of 284 participants (mean age: 41.7 years, mean spherical equivalent: - 7.70 D, and mean AL: 26.6 mm), 335 eyes (63.2%) had temporal disc torsion (temporal group) and 195 eyes (36.8%) had nasal disc torsion (nasal group). For the nasal group, a larger OI was associated with thinner superior-to-superonasal GCIPL (β = - 7.465 to - 6.972, both P = 0.024) and temporal RNFL sectors (β = - 49.596 to - 27.748, P ≤ 0.014). For the temporal group, a larger OI was associated with thinner superior-to-nasal (β = - 50.255 to - 22.093, P ≤ 0.006) and thicker temporal RNFL sectors (β = 29.015 to 56.890, P ≤ 0.003). Additionally, a larger HDT angle was associated with thinner superior-to-nasal RNFL sectors (β = - 0.559 to - 0.242, P ≤ 0.036) and thinner superior-to-superotemporal GCIPL sectors (β = - 0.084 to - 0.069, P ≤ 0.037).
The optic disc tortional direction was associated with the measurement of different RNFL and GCIPL sectors independent of the AL and age. These should be considered when constructing a myopic normative database.
探讨视盘扭转（ODT）、水平视盘倾斜（HDT）角度和椭圆率指数（OI）对健康近视眼中不同视网膜神经纤维层（RNFL）和神经节细胞-内丛状层（GCIPL）节段的影响。
从眼底照片测量ODT和OI。通过扫频光学相干断层扫描（SS-OCT）测量HDT角度、视乳头周围RNFL和黄斑GCIPL。评估视盘形态与RNFL/GCIPL厚度之间的关联，并对年龄和眼轴长度（AL）进行校正。
在284名参与者的530只健康近视眼中（平均年龄：41.7岁，平均等效球镜度数：-7.70D，平均AL：26.6mm），335只眼（63.2%）有颞侧视盘扭转（颞侧组），195只眼（36.8%）有鼻侧视盘扭转（鼻侧组）。对于鼻侧组来说，较大的OI与上象限至上鼻侧象限的GCIPL较薄（β=-7.465至-6.972，P均=0.024）以及颞侧RNFL节段较薄（β=-49.596至-27.748，P≤0.014）相关。对于颞侧组，较大的OI与上象限至鼻侧象限的RNFL较薄（β=-50.255至-22.093，P≤0.006）以及颞侧RNFL节段较厚（β=29.015至56.890，P≤0.003）相关。此外，较大的HDT角度与上象限至鼻侧象限的RNFL节段较薄（β=-0.559至-0.242，P≤0.036）以及上象限至上颞侧象限的GCIPL节段较薄（β=-0.084至-0.069，P≤0.037）相关。
视盘扭转方向与不同RNFL和GCIPL节段的测量值相关，且不受AL和年龄的影响。在构建近视规范数据库时应考虑这些因素。
