Chakraborty R
Genet Epidemiol. 1986;3(1):1-15. doi: 10.1002/gepi.1370030102.
The inheritance of pyloric stenosis is explained by a multifactorial threshold model with an underlying assumption that the liability for the disease is distributed in males and females showing a sex dimorphism. From the available data on familial occurrences of pyloric stenosis, it is shown, that an extra maternal effect is not required to explain the familial risk of pyloric stenosis, as opposed to the earlier literature. Explicit expressions for familial risks of a discontinuous trait exhibiting dimorphism of liability are presented, based on a model originally proposed by Rice et al [1981], which do not require the approximation of univariate normality of a conditional bivariate normal distribution.
幽门狭窄的遗传现象可通过多因素阈值模型来解释，该模型的一个基本假设是，疾病易感性在男性和女性中呈性别二态分布。与早期文献相反，从现有的幽门狭窄家族发病数据可知，解释幽门狭窄的家族风险并不需要额外的母体效应。基于赖斯等人[1981年]最初提出的模型，给出了具有易感性二态性的不连续性状家族风险的明确表达式，该模型不需要对条件双变量正态分布的单变量正态性进行近似。
