Lathrop G M, Lalouel J M, White R L
Genet Epidemiol. 1986;3(1):39-52. doi: 10.1002/gepi.1370030105.
Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large-scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an application to loci on chromosome 13.
文中给出了在由祖父母、父母和子女组成的家庭中进行多位点连锁似然性高效计算的方法。此类家庭正被用于大规模合作项目中，以构建人类基因组的详细连锁图谱。通过应用于13号染色体上的基因座对这些方法进行了说明。
