奥洛罗芬对多种菌种具有活性，包括对氟康唑活性降低的分离菌株。
Olorofim demonstrates activity against species, including isolates against which fluconazole has reduced activity.
作者信息
Wiederhold Nathan P, Patterson Hoja P, Ferrer Dora, Garcia Victor, Thompson George R, Patterson Thomas F
机构信息
Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2025 Jan 31;69(1):e0098824. doi: 10.1128/aac.00988-24. Epub 2024 Nov 21.
We evaluated the activity of olorofim against species. Olorofim demonstrated potent activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008-0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008-0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).
我们评估了奥洛罗芬对多种菌种的活性。奥洛罗芬对所有测试分离株均表现出强效活性，最低抑菌浓度（MIC）范围≤0.008 - 0.06 µg/mL，几何平均MIC为0.010 µg/mL。对于氟康唑MIC升高（≥16 µg/mL）的分离株，包括MIC≥32 µg/mL的菌株，这种活性也得以维持（奥洛罗芬MIC范围分别为≤0.008 - 0.06 µg/mL，几何平均MIC分别≤0.009和≤0.013 µg/mL）。
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