斯普拉格-道利大鼠的自发性脑肿瘤。

Spontaneous brain tumours in Sprague-Dawley rats.

作者信息

Gopinath C

出版信息

Food Chem Toxicol. 1986 Feb;24(2):113-20. doi: 10.1016/0278-6915(86)90345-5.

Abstract

Data were collected over a 5-yr period on brain tumours occurring spontaneously among Sprague-Dawley-derived rats in the HRC laboratories. Gliomas, like meningiomas, tended to occur more among males than in females, and in general appeared to be lesions of older rats. Astrocytic tumours of rats were less differentiated than those in man. The characteristic patterns of human glioblastoma multiforme were not observed in this series. Most of the astrocytomas were located in the cerebral areas. Secondary deposits observed in brain included those from tumours of Zymbal's gland, squamous-cell carcinoma, mammary adenocarcinoma, osteosarcoma and lymphoreticular neoplasms.

摘要

在5年时间里，收集了HRC实验室中斯普拉格-道利大鼠自发发生的脑肿瘤数据。胶质瘤和脑膜瘤一样，雄性比雌性更易发生，总体上似乎是老年大鼠的病变。大鼠的星形细胞瘤分化程度低于人类。本系列未观察到人类多形性胶质母细胞瘤的特征性模式。大多数星形细胞瘤位于脑区。在脑中观察到的继发性沉积物包括来自齐默尔氏腺肿瘤、鳞状细胞癌、乳腺腺癌、骨肉瘤和淋巴网状肿瘤的沉积物。